Selected Publications

Selected publications and link to publication list (when available) of EPN members

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Andreasson Anna

Andreasson A, Wicksell RK, Lodin K, Karshikoff B, Axelsson J, Lekander M. A Global Measure of Sickness Behavior: Development of the Sickness Questionnaire. J Health Psychol, 2016, pii: 1359105316659917. doi: 10.1177/1359105316659917.

Warnoff C, Lekander M, Hemmingsson T, Sorjonen K, Melin B, Andreasson A. Is poor self-rated health associated with low-grade inflammation in 43,110 late adolescent men of the general population? A cross-sectional study. BMJOpen, 2016, 6(4):e009440. doi: 10.1136/bmjopen-2015-009440.

Andreasson A, Schiller H, Åkerstedt T, Berntson E, Kecklund G, Lekander M. Brief report: Contemplate your symptoms and re-evaluate your health. A study on working adults. J Health Psychol, 2017, Jun 1:1359105317715090. doi: 10.1177/1359105317715090.

Lodin K, Lekander M, Syk J, Alving K, Petrovic P, Andreasson A. Longitudinal co-variations between inflammatory cytokines, lung function and patient reported outcomes in patients with asthma. PLoS One, 2017, 12(9):e0185019. doi: 10.1371/journal.pone.0185019.

Lodin K, Lekander M, Syk J, Alving K, Andreasson A. Associations between self-rated health, sickness behaviour and inflammatory markers in primary care patients with allergic
asthma: a longitudinal study. NPJ Prim Care Respir Med, 2017, 27(1):67. doi: 10.1038/s41533-017-0068-0.
 

 

Axelsson John

Axelsson J, Sundelin T, Olsson MJ, Sorjonen K, Axelsson C, Lasselin J, Lekander M. Identification of acutely sick people and facial cues of sickness. Proc Biol Sci, 2018, 285(1870). pii: 20172430. doi: 10.1098/rspb.2017.2430.

Karshikoff B, Jensen KB, Kosek E, Kalpouzos G, Soop A, Ingvar M, Olgart Höglund C, Lekander M, Axelsson J. Why sickness hurts: A central mechanism for pain induced by peripheral inflammation. Brain Behav Immun, 2016, 57:38-46. doi: 10.1016/j.bbi.2016.04.001.

Karshikoff B, Lekander M, Soop A, Lindstedt F, Ingvar M, Kosek E, Olgart Höglund C, Axelsson J. Modality and sex differences in pain sensitivity during human endotoxemia. Brain Behav Immun, 2015, 46:35-43. doi: 10.1016/j.bbi.2014.11.014.

Sundelin T, Karshikoff B, Axelsson E, Höglund CO, Lekander M, Axelsson J. Sick man walking: Perception of health status from body motion. Brain Behav Immun, 2015, 48:53-6. doi: 10.1016/j.bbi.2015.03.007.

Kecklund G, Axelsson J. Health consequences of shift work and insufficient sleep. BMJ, 2016, 355:i5210. doi: 10.1136/bmj.i5210.

Publication list
 

  

  

Ben-Eliyahu Shamgar

Benish M, Bartal I, Goldfarb Y, Levi B, Avraham R, Raz A, Ben-Eliyahu, S. Perioperative use of beta-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis. Ann Surg Oncol, 2008, 15(7):2042-2052. doi: 10.1245/s10434-008-9890-5.

Glasner A, Avraham R, Rosenne E, Benish M, Zmora O, Shemer S, Meiboom H, Ben-Eliyahu S. Improving survival rates in two models of spontaneous postoperative metastasis in mice by combined administration of a beta-adrenergic antagonist and a cyclooxygenase-2 inhibitor. Journal of Immunology, 2010, 184:2449-2457. doi: 10.4049/jimmunol.0903301.

Horowitz M, Neeman E, Sharon E, Ben-Eliyahu S. Exploiting the critical perioperative period to improve long-term cancer outcomes. Nat Rev Clin Oncol, 2015, 4:213-26. doi: 10.1038/nrclinonc.2014.224.

Sorski L, Melamed R, Matzner P, Lavon H, Shaashua L, Rosenne E, Ben-Eliyahu S. Reducing liver metastases of colon cancer in the context of extensive and minor surgeries through beta-adrenoceptors blockade and COX2 inhibition. Brain Behav Immun, 2016, 58:91-98. doi: 10.1016/j.bbi.2016.05.017.

Shaashua L, Shabat-Simon M, Haldar R, Matzner P, Zmora O, Shabtai M, Sharon E, Allweis T, Barshack I, Hayman L, Arevalo J, Ma J, Horowitz M, Cole S, Ben-Eliyahu S. Perioperative COX-2 andβ-adrenergic blockade improves metastatic biomarkers in breast cancer patients in a phase-II randomized trial. Clinical Cancer Research, 2017, 23(16):4651-4661. doi: 10.1158/1078-0432.CCR-17-0152.
 

 

Benros Michael

Benros ME, Nielsen PR, Nordentoft M, Eaton WW, Dalton SO, Mortensen PB. Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study. Am J Psychiatry. 2011 Dec;168(12):1303-10. doi: 10.1176/appi.ajp.2011.11030516.

Benros ME, Waltoft BL, Nordentoft M, Ostergaard SD, Eaton WW, Krogh J, Mortensen PB. Autoimmune diseases and severe infections as risk factors for mood disorders: a nationwide study. JAMA Psychiatry, 2013, 70(8):812-20. doi: 10.1001/jamapsychiatry.2013.1111.

Köhler O, Benros ME, Nordentoft M, Farkouh ME, Iyengar RL, Mors O, Krogh J. Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trials. JAMA Psychiatry, 2014, 71(12):1381-91. doi: 10.1001/jamapsychiatry.2014.1611.

Benros ME, Trabjerg BB, Meier S, Mattheisen M, Mortensen PB, Mors O, Børglum AD, Hougaard DM, Nørgaard-Pedersen B, Nordentoft M, Agerbo E. Influence of Polygenic Risk Scores on the Association Between Infections and Schizophrenia. Biol Psychiatry, 2016, 80(8):609-16. doi: 10.1016/j.biopsych.2016.04.008.

Orlovska S, Vestergaard CH, Bech BH, Nordentoft M, Vestergaard M, Benros ME. Association of Streptococcal Throat Infection With Mental Disorders: Testing Key Aspects of the PANDAS Hypothesis in a Nationwide Study. JAMA Psychiatry, 2017, 74(7):740-746. doi: 10.1001/jamapsychiatry.2017.0995.

Publication list

 

 

Benson Sven

Lasselin J, Lekander M, Benson S, Schedlowski M, Engler H. Sick for science: experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression. Mol Psychiatry, 2020. doi: 10.1038/s41380-020-00869-2.

Benson S, Siebert C, Koenen LR, Engler H, Kleine-Borgmann J, Bingel U, Icenhour A, Elsenbruch S. Cortisol affects pain sensitivity and pain-related emotional learning in experimental visceral but not somatic pain: a randomized controlled study in healthy men and women. Pain, 2019, 160(8):1719-1728. doi: 10.1097/j.pain.0000000000001579.

Benson S, Brinkhoff A, Lueg L, Roderigo T, Kribben A, Wilde B, Witzke O, Engler H, Schedlowski M, Elsenbruch S. Effects of acute systemic inflammation on the interplay between sad mood and affective cognition. Transl Psychiatry, 2017, 7(12):1281. doi: 10.1038/s41398-017-0043-0.

Engler H, Brendt P, Wischermann J, Wegner A, Röhling R, Schoemberg T, Meyer U, Gold R, Peters J, Benson S, Schedlowski M. Selective increase of cerebrospinal fluid IL-6 during experimental systemic inflammation in humans: association with depressive symptoms. Mol Psychiatry, 2017, 22(10):1448-1454. doi: 10.1038/mp.2016.264.

Benson S, Engler H, Wegner A, Rebernik L, Spreitzer I, Schedlowski M, Elsenbruch S. What Makes You Feel Sick After Inflammation? Predictors of Acute and Persisting Physical Sickness Symptoms Induced by Experimental Endotoxemia. Clin Pharmacol Ther, 2017, 102(1):141-151. doi: 10.1002/cpt.618.

Publication list

 

  

Blomqvist Anders

Blomqvist A, Engblom D. Neural Mechanisms of Inflammation-Induced Fever. Neuroscientist, 2018, 24(4):381-399. doi: 10.1177/1073858418760481

Eskilsson A, Mirrasekhian E, Dufour S, Schwaninger M, Engblom D, Blomqvist A. Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to STAT3-dependent induction of brain endothelial prostaglandin synthesis. J Neurosci, 2014, 34(48):15957-61. doi: 10.1523/JNEUROSCI.3520-14.2014

Engblom D, Saha S, Engström L, Westman M, Audoly LP, Jakobsson PJ, Blomqvist A. Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis. Nat Neurosci, 2003, 6(11):1137-8. doi: 10.1038/nn1137

Engström L, Ruud J, Eskilsson A, Larsson A, Mackerlova L, Kugelberg U, Qian H, Vasilache AM, Larsson P, Engblom D, Sigvardsson M, Jönsson JI, Blomqvist A. Lipopolysaccharide-induced fever depends on prostaglandin E2 production specifically in brain endothelial cells. Endocrinology, 2012, 153(10):4849-61. doi: 10.1210/en.2012-1375

Vasilache AM, Qian H, Blomqvist A. Immune challenge by intraperitoneal administration of lipopolysaccharide directs gene expression in distinct blood-brain barrier cells toward enhanced prostaglandin E(2) signaling. Brain Behav Immun, 2015, 48:31-41. doi: 10.1016/j.bbi.2015.02.003.

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Børsting Jacobsen Henrik

Jacobsen HB, Stubhaug A, Schirmer H, Inge Landrø N, Wilsgaard T, Mathiesen EB, Nielsen CS. Neuropsychological functions of verbal recall and psychomotor speed significantly affect pain tolerance. Eur J Pain. 2019 Oct;23(9):1608-1618. doi: 10.1002/ejp.1437

Myhre M, Jacobsen HB, Andersson S, Stubhaug A. Cognitive Effects of Perioperative Pregabalin: Secondary Exploratory Analysis of a Randomized Placebo-controlled Study. Anesthesiology. 2019 Jan;130(1):63-71. doi: 10.1097/ALN.0000000000002473

Jacobsen HB, Reme SE, Sembajwe G, Hopcia K, Stiles TC, Sorensen G, Porter JH, Marino M, Buxton OM. Work stress, sleep deficiency, and predicted 10-year cardiometabolic risk in a female patient care worker population. Am J Ind Med. 2014 Aug;57(8):940-9. doi: 10.1002/ajim.22340

Jacobsen HB, Bjørngaard JH, Hara KW, Borchgrevink PC, Woodhouse A, Landrø NI, Harris A, Stiles TC. The role of stress in absenteeism: cortisol responsiveness among patients on long-term sick leave. PLoS One. 2014 May 2;9(5):e96048. doi: 10.1371/journal.pone.0096048.

Kallestad H, Jacobsen HB, Landrø NI, Borchgrevink PC, Stiles TC. The role of insomnia in the treatment of chronic fatigue. J Psychosom Res. 2015 May;78(5):427-32. doi: 10.1016/j.jpsychores.2014.11.022.

Publication list

 

  

Bosch Jos

Balter LJ, Bosch JA, Aldred S, Drayson MT, Veldhuijzen van Zanten JJ, Higgs S, Raymond JE, Mazaheri A. Selective effects of acute low-grade inflammation on human visual attention. Neuroimage, 2019, 202:116098. doi: 10.1016/j.neuroimage.2019.116098

Balter LJT, Raymond JE, Aldred S, Drayson MT, Veldhuijzen van Zanten JJCS, Higgs S, Bosch JA. Loneliness in healthy young adults predicts inflammatory responsiveness to a mild immune challenge in vivo. Brain Behav Immun, 2019, 82:298-301. doi: 10.1016/j.bbi.2019.08.196

Schakel L, Veldhuijzen DS, Crompvoets PI, Bosch JA, Cohen S, van Middendorp H, Joosten SA, Ottenhoff THM, Visser LG, Evers AWM. Effectiveness of Stress-Reducing Interventions on the Response to Challenges to the Immune System: A Meta-Analytic Review. Psychother Psychosom, 2019, 88(5):274-286. doi: 10.1159/000501645

Engeland CG, Bosch JA, Rohleder N. Salivary Biomarkers in Psychoneuroimmunology. Curr Opin Behav Sci, 2019, 28:58-65. doi: 10.1016/j.cobeha.2019.01.007.

Balter LJT, Hulsken S, Aldred S, Drayson MT, Higgs S, Veldhuijzen van Zanten JJCS, Raymond JE, Bosch JA. Low-grade inflammation decreases emotion recognition – Evidence from the vaccination model of inflammation. Brain Behav Immun, 2018, 73:216-221. doi: 10.1016/j.bbi.2018.05.006.

Publication list

 

 

  

Capellino Silvia

Capellino S, Cosentino M, Luini A, Bombelli R, Lowin T, Cutolo M, Marino F, Straub RH. Increased expression of dopamine receptors in synovial fibroblasts from patients with rheumatoid arthritis: inhibitory effects of dopamine on interleukin-8 and interleukin-6. Arthritis Rheumatol, 2014, 66(10):2685-93. doi: 10.1002/art.38746.

Capellino S, Weber K, Gelder M, Härle P, Straub RH. First appearance and location of catecholaminergic cells during experimental arthritis and elimination by chemical sympathectomy. Arthritis Rheum, 2012, 64(4):1110-8. doi: 10.1002/art.33431.

Capellino S, Cosentino M, Wolff C, Schmidt M, Grifka J, Straub RH. Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target. Ann Rheum Dis, 2010, 69(10):1853-60. doi: 10.1136/ard.2009.119701.

Straub RH, Grum F, Strauch U, Capellino S, Bataille F, Bleich A, Falk W, Schölmerich J, Obermeier F. Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation. Gut, 2008, 57(7):911-21. doi: 10.1136/gut.2007.125401.

Cutolo M, Capellino S, Sulli A, Serioli B, Secchi ME, Villaggio B, Straub RH. Estrogens and autoimmune diseases. Ann N Y Acad Sci, 2006, 1089:538-47. doi: 10.1196/annals.1386.043.

Publication list

 

  

Castanon Nathalie

Fourrier C, Bosch-Bouju C, Boursereau R, Sauvant J, Aubert A, Capuron L, Ferreira G, Layé S, Castanon N. Brain tumor necrosis factor-α mediates anxiety-like behavior in a mouse model of severe obesity. Brain Behav Immun. 2019 Mar;77:25-36. doi: 10.1016/j.bbi.2018.11.316.

Vancassel S, Capuron L, Castanon N. Brain Kynurenine and BH4 Pathways: Relevance to the Pathophysiology and Treatment of Inflammation-Driven Depressive Symptoms. Front Neurosci. 2018 Jul 24;12:499. doi: 10.3389/fnins.2018.00499.

Capuron L, Lasselin J, Castanon N. Role of Adiposity-Driven Inflammation in Depressive Morbidity. Neuropsychopharmacology. 2017 Jan;42(1):115-128. doi: 10.1038/npp.2016.123.

de Cossío LF, Fourrier C, Sauvant J, Everard A, Capuron L, Cani PD, Layé S, Castanon N. Impact of prebiotics on metabolic and behavioral alterations in a mouse model of metabolic syndrome. Brain Behav Immun. 2017 Aug;64:33-49. doi: 10.1016/j.bbi.2016.12.022.

Dinel AL, André C, Aubert A, Ferreira G, Layé S, Castanon N. Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in a mouse model of metabolic syndrome. Psychoneuroendocrinology. 2014 Feb;40:48-59. doi: 10.1016/j.psyneuen.2013.10.014.

 

  

Chiu Lynn

Publication list

 

  

Cosentino Marco

Kustrimovic N, Comi C, Magistrelli L, Rasini E, Legnaro M, Bombelli R, Aleksic I, Blandini F, Minafra B, Riboldazzi G, Sturchio A, Mauri M, Bono G, Marino F, Cosentino M. Parkinson’s disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients. J Neuroinflammation, 2018, 15(1):205. doi: 10.1186/s12974-018-1248-8.

Marino F, Scanzano A, Pulze L, Pinoli M, Rasini E, Luini A, Bombelli R, Legnaro M, de Eguileor M, Cosentino M. β2 -Adrenoceptors inhibit neutrophil extracellular traps in human polymorphonuclear leukocytes. J Leukoc Biol, 2018, 104(3):603-614. doi: 10.1002/JLB.3A1017-398RR.

Cosentino M, Kustrimovic N, Ferrari M, Rasini E, Marino F. cAMP levels in lymphocytes and CD4+ regulatory T-cell functions are affected by dopamine receptor gene polymorphisms. Immunology, 2018, 153(3):337-341. doi: 10.1111/imm.12843.

Pinoli M, Marino F, Cosentino M. Dopaminergic Regulation of Innate Immunity: a Review. J Neuroimmune Pharmacol, 2017, 12(4):602-623. doi: 10.1007/s11481-017-9749-2.

Marino F, Cosentino M. Multiple sclerosis: Repurposing dopaminergic drugs for MS-the evidence mounts. Nat Rev Neurol, 2016, 12(4):191-2. doi: 10.1038/nrneurol.2016.33.

Publication list

 

  

Cunningham Colm

Nazmi A, Field RH, Griffin EW, Haugh O, Hennessy E, Cox D, Reis R, Tortorelli L, Murray CL, Lopez-Rodriguez AB, Jin L, Lavelle EC, Dunne A, Cunningham C. Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression. Version 2. Glia. 2019 Jul;67(7):1254-1276. doi: 10.1002/glia.23592.

Skelly DT, Griffin ÉW, Murray CL, Harney S, O’Boyle C, Hennessy E, Dansereau MA, Nazmi A, Tortorelli L, Rawlins JN, Bannerman DM, Cunningham C. Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms. Version 2. Mol Psychiatry. 2019 Oct;24(10):1533-1548. doi: 10.1038/s41380-018-0075-8.

Davis DHJ, Skelly DT, Murray C, Hennessy E, Bowen J, Norton S, Brayne C, Rahkonen T, Sulkava R, Sanderson DJ, Rawlins JN, Bannerman DM, MacLullich AMJ, Cunningham C. Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium. Version 2. Am J Geriatr Psychiatry. 2015 Apr;23(4):403-415. doi: 10.1016/j.jagp.2014.08.005.

Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci. 2005 Oct 5;25(40):9275-84. doi: 10.1523/JNEUROSCI.2614-05.2005.

Hennessy E, Griffin ÉW, Cunningham C. Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1β and TNF-α. J Neurosci. 2015 Jun 3;35(22):8411-22. doi: 10.1523/JNEUROSCI.2745-14.2015.

 

  

  

Dantzer Robert

Walker AK, Wing EE, Banks WA, Dantzer R. Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice. Mol Psychiatry, 2018. doi: 10.1038/s41380-018-0076-7.

Lacourt TE, Vichaya EG, Escalante C, Manzullo EF, Gunn B, Hess KR, Heijnen CJ, Dantzer R. An effort expenditure perspective on cancer-related fatigue. Psychoneuroendocrinology, 2018, 96:109-117. doi: 10.1016/j.psyneuen.2018.06.009.

Dantzer R. Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa. Physiol Rev, 2018, 98(1):477-504. doi: 10.1152/physrev.00039.2016.

Grossberg AJ, Vichaya EG, Christian DL, Molkentine JM, Vermeer DW, Gross PS, Vermeer PD, Lee JH, Dantzer R. Tumor-Associated Fatigue in Cancer Patients Develops Independently of IL1 Signaling. Cancer Res, 2018, 78(3):695-705. doi: 1158/0008-5472.CAN-17-2168.

VichayaEG, Laumet G, Christian DL, Grossberg AJ, Estrada DJ, Heijnen CJ, Kavelaars A, Dantzer R. Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2,3 dioxygenase. Neuropsychopharmacology, 2018. doi: 10.1038/s41386-018-0075-z.

 

  

Darnaudéry Muriel

Rincel M, Aubert P, Chevalier J, Grohard PA, Basso L, Monchaux de Oliveira C, Helbling JC, Lévy É, Chevalier G, Leboyer M, Eberl G, Layé S, Capuron L, Vergnolle N, Neunlist M, Boudin H, Lepage P, Darnaudéry M. Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner. Brain Behav Immun. 2019 Aug;80:179-192. doi: 10.1016/j.bbi.2019.03.006

Rincel M, Olier M, Minni A, Monchaux de Oliveira C, Matime Y, Gaultier E, Grit I, Helbling JC, Costa AM, Lépinay A, Moisan MP, Layé S, Ferrier L, Parnet P, Theodorou V, Darnaudéry M. Pharmacological restoration of gut barrier function in stressed neonates partially reverses long-term alterations associated with maternal separation. Psychopharmacology (Berl). 2019 May;236(5):1583-1596. doi: 10.1007/s00213-019-05252-w

Gueye AB, Vendruscolo LF, de Ávila C, Le Moine C, Darnaudéry M, Cador M. Unlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood. Neuropsychopharmacology. 2018 Dec;43(13):2627-2635. doi: 10.1038/s41386-018-0025-9

Rincel M, Lépinay AL, Janthakhin Y, Soudain G, Yvon S, Da Silva S, Joffre C, Aubert A, Séré A, Layé S, Theodorou V, Ferreira G, Darnaudéry M. Maternal high-fat diet and early life stress differentially modulate spine density and dendritic morphology in the medial prefrontal cortex of juvenile and adult rats. Brain Struct Funct. 2018 Mar;223(2):883-895. doi: 10.1007/s00429-017-1526-8

Rincel M, Lépinay AL, Delage P, Fioramonti J, Théodorou VS, Layé S, Darnaudéry M. Maternal high-fat diet prevents developmental programming by early-life stress. Transl Psychiatry. 2016 Nov 29;6(11):e966. doi: 10.1038/tp.2016.235.

Publication list

 

  

De Palma Giada

De Palma G, Lynch MD, Lu J, Dang VT, Deng Y, Jury J, Umeh G, Miranda PM, Pigrau Pastor M, Sidani S, Pinto-Sanchez MI, Philip V, McLean PG, Hagelsieb MG, Surette MG, Bergonzelli GE, Verdu EF, Britz-McKibbin P, Neufeld JD, Collins SM, Bercik P. Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice. Sci Transl Med. 2017 Mar 1;9(379):eaaf6397. doi: 10.1126/scitranslmed.aaf6397

De Palma G, Blennerhassett P, Lu J, Deng Y, Park AJ, Green W, Denou E, Silva MA, Santacruz A, Sanz Y, Surette MG, Verdu EF, Collins SM, Bercik P. Microbiota and host determinants of behavioural phenotype in maternally separated mice. Nat Commun. 2015 Jul 28;6:7735. doi: 10.1038/ncomms8735

Miranda PM, De Palma G, Serkis V, Lu J, Louis-Auguste MP, McCarville JL, Verdu EF, Collins SM, Bercik P. High salt diet exacerbates colitis in mice by decreasing Lactobacillus levels and butyrate production. Microbiome. 2018 Mar 22;6(1):57. doi: 10.1186/s40168-018-0433-4

Pinto-Sanchez MI, Hall GB, Ghajar K, Nardelli A, Bolino C, Lau JT, Martin FP, Cominetti O, Welsh C, Rieder A, Traynor J, Gregory C, De Palma G, Pigrau M, Ford AC, Macri J, Berger B, Bergonzelli G, Surette MG, Collins SM, Moayyedi P, Bercik P. Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome. Gastroenterology. 2017 Aug;153(2):448-459.e8. doi: 10.1053/j.gastro.2017.05.003.

Gorbovskaya I, Kanji S, Liu JCW, MacKenzie NE, Agarwal SM, Marshe VS, Sriretnakumar V, Verdu EF, Bercik P, De Palma G, Hahn MK, Müller DJ. Investigation of the Gut Microbiome in Patients with Schizophrenia and Clozapine-Induced Weight Gain: Protocol and Clinical Characteristics of First Patient Cohorts. Neuropsychobiology. 2020;79(1):5-12. doi: 10.1159/000494696

Publication list

 

  

de Punder Karin

de Punder K, Entringer S, Heim C, Deuter CE, Otte C, Wingenfeld K, Kuehl LK. Inflammatory Measures in Depressed Patients With and Without a History of Adverse Childhood Experiences. Front Psychiatry, 2018, 9:610. doi: 10.3389/fpsyt.2018.00610

de Punder K, Heim C, Wadhwa PD, Entringer S. Stress and immunosenescence: The role of telomerase. Psychoneuroendocrinology, 2018, 101:87-100. doi: 10.1016/j.psyneuen.2018.10.019

Entringer S, de Punder K, Buss C, Wadhwa PD. The fetal programming of telomere biology hypothesis: an update. Philos Trans R Soc Lond B Biol Sci, 2018, 373(1741), pii: 20170151. doi: 10.1098/rstb.2017.0151

de Punder K, Heim C, Przesdzing I, Wadhwa PD, Entringer S. Characterization in humans of in vitro leucocyte maximal telomerase activity capacity and association with stress. Philos Trans R Soc Lond B Biol Sci, 2018, 373(1741), pii: 20160441. doi: 10.1098/rstb.2016.0441

de Punder K, Pruimboom L. Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability. Front Immunol, 2015, 6:223. doi: 10.3389/fimmu.2015.00223

Publication list

 

  

  

Eisel Ulrich

Dong Y, Fischer R, Naudé PJ, Maier O, Nyakas C, Duffey M, Van der Zee EA, Dekens D, Douwenga W, Herrmann A, Guenzi E, Kontermann RE, Pfizenmaier K, Eisel UL. Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration. Proc Natl Acad Sci U S A, 2016, 113(43):12304-12309. doi: 10.1073/pnas.1605195113.

Ostroveanu A, van der Zee EA, Eisel UL, Schmidt M, Nijholt IM. Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval. Hippocampus, 2010, 20(9):1018-26. doi: 10.1002/hipo.20700.

Marchetti L, Klein M, Schlett K, Pfizenmaier K, Eisel UL. Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem, 2004, 279(31):32869-81. doi: 10.1074/jbc.M311766200.

Williams SK, Fairless R, Maier O, Liermann PC, Pichi K, Fischer R, Eisel ULM, Kontermann R, Herrmann A, Weksler B, Romero N, Couraud PO, Pfizenmaier K, Diem R. Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis. Sci Rep, 2018, 8(1):13628. doi: 10.1038/s41598-018-31957-7.

Blank T, Detje CN, Spieß A, Hagemeyer N, Brendecke SM, Wolfart J, Staszewski O, Zöller T, Papageorgiou I, Schneider J, Paricio-Montesinos R, Eisel UL, Manahan-Vaughan D, Jansen S, Lienenklaus S, Lu B, Imai Y, Müller M, Goelz SE, Baker DP, Schwaninger M, Kann O, Heikenwalder M, Kalinke U, Prinz M. Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment. Immunity, 2016, 44(4):901-12. doi: 10.1016/j.immuni.2016.04.005.

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Elsenbruch Sigrid

Benson S, Kattoor J, Wegner A, Hammes F, Reidick D, Grigoleit JS, Engler H, Oberbeck R, Schedlowski M, Elsenbruch S. Acute experimental endotoxemia induces visceral hypersensitivity and altered pain evaluation in healthy humans. Pain, 2012, 153(4):794-9. doi: 10.1016/j.pain.2011.12.001.

Benson S, Rebernik L, Wegner A, Kleine-Borgmann J, Engler H1, Schlamann M, Forsting M, Schedlowski M, Elsenbruch S. Neural circuitry mediating inflammation-induced central pain amplification in human experimental endotoxemia. Brain Behav Immun, 2015, 48:222-31. doi: 10.1016/j.bbi.2015.03.017.

Engler H, Benson S, Wegner A, Spreitzer I, Schedlowski M, Elsenbruch S. Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms. Brain Behav Immun, 2016, 52:18-26. doi: 10.1016/j.bbi.2015.08.013.

Benson S, Engler H, Wegner A, Rebernik L, Spreitzer I, Schedlowski M, Elsenbruch S. What Makes You Feel Sick After Inflammation? Predictors of Acute and Persisting Physical Sickness Symptoms Induced by Experimental Endotoxemia. Clin Pharmacol Ther, 2017, 102(1):141-151. doi: 10.1002/cpt.618.

Benson S, Brinkhoff A, Lueg L, Roderigo T, Kribben A, Wilde B, Witzke O, Engler H, Schedlowski M, Elsenbruch S. Effects of acute systemic inflammation on the interplay between sad mood and affective cognition. Transl Psychiatry, 2017, 7(12):1281. doi: 10.1038/s41398-017-0043-0.
 

 

Engler Harald

Engler H, Brendt P, Wischermann J, Wegner A, Röhling R, Schoemberg T, Meyer U, Gold R, Peters J, Benson S, Schedlowski M. Selective increase of cerebrospinal fluid IL-6 during experimental systemic inflammation in humans: association with depressive symptoms. Mol Psychiatry, 2017, 22:1448-1454. doi: 10.1038/mp.2016.264.

Giovanoli S, Weber-Stadlbauer U, Schedlowski M, Meyer U, Engler H. Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies. Brain Behav Immun, 2016, 55:25-38. doi: 10.1016/j.bbi.2015.09.015.

Engler H, Benson S, Wegner A, Spreitzer I, Schedlowski M, Elsenbruch S. Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms. Brain Behav Immun, 2016, 52:18-26. doi: 10.1016/j.bbi.2015.08.013.

Giovanoli S, Engler H, Engler A, Richetto J, Voget M, Willi R, Winter C, Riva MA, Mortensen PB, Feldon J, Schedlowski M, Meyer U. Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice. Science, 2013, 339:1095-1099. doi: 10.1126/science.1228261.

Engler H, Doenlen R, Engler A, Riether C, Prager G, Niemi MB, Pacheco-López G, Krügel U, Schedlowski M. Acute amygdaloid response to systemic inflammation. Brain Behav Immun, 2011, 25:1384-1392. doi: 10.1016/j.bbi.2011.04.005.
 

 

  

Fetissov Sergueï

Fetissov SO. Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour. Nat Rev Endocrinol, 2017, 13:11-25. doi: 10.1038/nrendo.2016.150.

Værøy H, Adori C, Legrand R, Lucas N, Breton J, Cottard C, do Rego JC, Duparc C, Louiset E, Lefebvre H, Déchelotte P, Western E, Andersson S, Hökfelt T, Fetissov SO. Autoantibodies reactive to adrenocorticotropic hormone can alter cortisol secretion in both aggressive and nonaggressive humans. Proc Natl Acad Sci USA, 2018, 115:E6576-E6584. doi: 10.1073/pnas.1720008115.

Lucas N, Legrand R, Bôle-Feysot C, Breton J, Coëffier M, Akkermann K, Järv A, Harro J, Déchelotte P, Fetissov SO. Immunoglobulin G modulation of the melanocortin 4 receptor signaling in obesity and eating disorders. Translational Psychiatry, 2019, 9(1):87. doi: 10.1038/s41398-019-0422-9.

Legrand R, Lucas N, Breton J, Déchelotte P, Fetissov SO. Dopamine release in the lateral hypothalamus is stimulated by α-MSH in both the anticipatory and consummatory phases of feeding. Psychoneuroendocrinology, 2015, 56:79-87. doi: 10.1016/j.psyneuen.2015.02.020.

Tennoune N, Chan P, Breton J, Legrand R, Chabane YN, Akkermann K, Jarv A, Ouelaa W, Takagi K, Ghouzali I, François M, Lucas N, Bole-Feysot C, Pestel-Caron M, do Rego JC, Vaudry D, Harro J, Dé E, Déchelotte P, Fetissov SO. Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide [alpha]-MSH, at the origin of eating disorders. Transl Psychiatry, 2014, 4:e458. doi: 10.1038/tp.2014.98.

 

 

  

Grigoleit Jan Sebastian

Bhattacharya A, Lord B, Grigoleit JS, He Y, Fraser I, Campbell SN, Taylor N, Aluisio L, O’Connor JC, Papp M, Chrovian C, Carruthers N, Lovenberg TW, Letavic MA. Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia. Neuropsychopharmacology, 2018, 43(13):2586-2596. doi: 10.1038/s41386-018-0141-6.

Serrats J, Grigoleit JS, Alvarez-Salas E, Sawchenko PE. Pro-inflammatory immune-to-brain signaling is involved in neuroendocrine responses to acute emotional stress. Brain Behav Immun, 2017, 62:53-63. doi: 10.1016/j.bbi.2017.02.003.

Lasselin J, Alvarez-Salas E, Grigoleit JS. Well-being and immune response: a multi-system perspective. Curr Opin Pharmacol, 2016, 29:34-41. doi: 10.1016/j.coph.2016.05.003.

Schedlowski M, Engler H, Grigoleit JS. Endotoxin-induced experimental systemic inflammation in humans: a model to disentangle immune-to-brain communication. Brain Behav Immun, 2014, 35:1-8. doi: 10.1016/j.bbi.2013.09.015.

Grigoleit JS, Kullmann JS, Wolf OT, Hammes F, Wegner A, Jablonowski S, Engler H, Gizewski E, Oberbeck R, Schedlowski M. Dose-dependent effects of endotoxin on neurobehavioral functions in humans. PLoS One, 2011, 6(12):e28330. doi: 10.1371/journal.pone.0028330.

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Hadamitzky Martin

Hadamitzky M, Herring A, Kirchhof J, Bendix I, Haight MJ, Keyvani K, Luckemann L, Unteroberdorster M, Schedlowski M. Repeated Systemic Treatment with Rapamycin Affects Behavior and Amygdala Protein Expression in Rats. Int J Neuropsychopharmacol, 2018, 21:592-602. doi: 10.1093/ijnp/pyy017.

Lückemann L, Unteroberdorster M, Kirchhof J, Schedlowski M, Hadamitzky M. Applications and limitations of behaviorally conditioned immunopharmacological responses. Neurobiol Learn Mem, 2017, 142:91-98. doi: 10.1016/j.nlm.2017.02.012.

Hadamitzky M, Bosche K, Wirth T, Buck B, Beetz O, Christians U, Schniedewind B, Luckemann L, Gunturkun O, Engler H, Schedlowski M. Memory-updating abrogates extinction of learned immunosuppression. Brain Behav Immun, 2016, 52:40-48. doi: 10.1016/j.bbi.2015.09.009.

Lückemann L, Bosche K, Engler H, Schwitalla JC, Hadamitzky M, Schedlowski M. Preexposure to the unconditioned or conditioned stimulus does not affect learned immunosuppression in rats. Brain Behav Immun, 2016, 51:252-257. doi: 10.1016/j.bbi.2015.09.005.

Bosche K, Weissenborn K, Christians U, Witzke O, Engler H, Schedlowski M, Hadamitzky M. Neurobehavioral consequences of small molecule-drug immunosuppression. Neuropharmacology, 2015, 96:83-93. doi: 10.1016/j.neuropharm.2014.12.008.
 

  

Harrison Neil

Harrison NA, Cooper E, Dowell NG, Keramida G, Voon V, Critchley HD, Cercignani M. Quantitative Magnetization Transfer Imaging as a Biomarker for Effects of Systemic Inflammation on the Brain. Biol Psychiatry, 2015, 78(1):49-57. doi: 10.1016/j.biopsych.2014.09.023.

Harrison NA, Voon V, Cercignani M, Cooper EA, Pessiglione M, Critchley HD. A Neurocomputational Account of How Inflammation Enhances Sensitivity to Punishments Versus Rewards. Biol Psychiatry, 2016, 80(1):73-81. doi: 10.1016/j.biopsych.2015.07.018.

Harrison NA, Brydon L, Walker C, Gray MA, Steptoe A, Dolan RJ, Critchley HD. Neural origins of human sickness in interoceptive responses to inflammation. Biol Psychiatry, 2009, 66(5):415-22. doi: 10.1016/j.biopsych.2009.03.007.

Harrison NA, Brydon L, Walker C, Gray MA, Steptoe A, Critchley HD. Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biol Psychiatry, 2009, 66(5):407-14. doi: 10.1016/j.biopsych.2009.03.015.

Harrison NA. Brain Structures Implicated in Inflammation-Associated Depression. Curr Top Behav Neurosci, 2017, 31:221-248. doi: 10.1007/7854_2016_30.

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Jonsjö Martin

Jonsjö MA, Wicksell RK, Holmström L, Andreasson A, Bileviciute-Ljungar I, Olsson GL. Identifying symptom subgroups in patients with ME/CFS – relationships to functioning and quality of life, Fatigue: Biomedicine, Health & Behavior, 2017, 5:1, 33-42. doi: 10.1080/21641846.2017.1287546

Jonsjö MA, Åström J, Jones MP, Karshikoff B, Lodin K, Holmström L, Agréus L, Wicksell RK, Axelsson J, Lekander M, Olsson GL, Kemani M, Andreasson A. Patients with ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) and chronic pain report similar level of sickness behavior as individuals injected with bacterial endotoxin at peak inflammation. Brain, Behavior, & Immunity – Health, 2020, 100028. doi: 10.1016/j.bbih.2019.100028.

Jonsjö MA, Olsson GL, Wicksell RK, Alving K, Holmström L, Andreasson A. The role of low-grade inflammation in ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) – associations with symptoms. Psychoneuroendocrinology. 2020 Mar;113:104578. doi: 10.1016/j.psyneuen.2019.104578

 

 

  

Ivanovska Mariya

Vasileva LV, Saracheva KЕ, Ivanovska MV, Petrova AP, Sucouglu E, Murdjeva MA, Getova-Spasova DP. Beneficial Effect of Chronic Treatment with Extracts from Rhodiola Rosea L. and Curcuma Longa L. on the Immunoreactivity of Animals Subjected to a Chronic Mild Stress Model. Folia Med (Plovdiv), 2017, 59(4):443-453. doi: 10.1515/folmed-2017-0046

Sokolova RN, Yankova RK, Abadjieva TI, Popova TA, Ivanovska MV, Murdjeva MA, Orbetzova MM, Dermendzhiev SM, Pavlova MV. Association between Type 2 Diabetes, Obesity and Key Immunological Components of IgE-mediated Inflammation. Folia Med (Plovdiv), 2017, 59(2):159-164. doi: 10.1515/folmed-2017-0021

Vasileva LV, Saracheva KE, Ivanovska MV, Petrova AP, Marchev AS, Georgiev MI, Murdjeva MA, Getova DP. Antidepressant-like effect of salidroside and curcumin on the immunoreactivity of rats subjected to a chronic mild stress model. Food Chem Toxicol, 2018, 121:604-611. doi: 10.1016/j.fct.2018.09.065

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Karabatsiakis Alexander

Koenig AM, Karabatsiakis A, Stoll T, Wilker S, Hennessy T, Hill MM, Kolassa IT. Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study. Sci Rep. 2018 Feb 22;8(1):3468. doi: 10.1038/s41598-018-21763-6.

Karabatsiakis A, Böck C, Salinas-Manrique J, Kolassa S, Calzia E, Dietrich DE, Kolassa IT. Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression. Transl Psychiatry. 2014 Jun 10;4(6):e397. doi: 10.1038/tp.2014.44.

Boeck C, Pfister S, Bürkle A, Vanhooren V, Libert C, Salinas-Manrique J, Dietrich DE, Kolassa IT, Karabatsiakis A. Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder. J Affect Disord. 2018 Jul;234:139-147. doi: 10.1016/j.jad.2018.02.082.

Karabatsiakis A, Kolassa IT, Kolassa S, Rudolph KL, Dietrich DE. Telomere shortening in leukocyte subpopulations in depression. BMC Psychiatry. 2014 Jul 5;14:192. doi: 10.1186/1471-244X-14-192.

Karabatsiakis A, Hamuni G, Wilker S, Kolassa S, Renu D, Kadereit S, Schauer M, Hennessy T, Kolassa IT. Metabolite profiling in posttraumatic stress disorder. J Mol Psychiatry. 2015 Feb 8;3(1):2. doi: 10.1186/s40303-015-0007-3.

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Karshikoff Bianka

Lasselin J, Lekander M, Axelsson J, Karshikoff B. Sex differences in how inflammation affects behavior: What we can learn from experimental inflammatory models in humans. Front Neuroendocrinol, 2018, pii: S0091-3022(18)30047-5. doi: 10.1016/j.yfrne.2018.06.005.

Andreasson A, Wicksell RK, Lodin K, Karshikoff B, Axelsson J, Lekander M. A global measure of sickness behaviour: Development of the Sickness Questionnaire. J Health Psychol, 2018, 23(11):1452-1463. doi: 10.1177/1359105316659917.

Tamm S, Cervenka S, Forsberg A, Estelius J, Grunewald J, Gyllfors P, Karshikoff B, Kosek E, Lampa J, Lensmar C, Strand V, Åkerstedt T, Halldin C, Ingvar M, Olgart Höglund C, Lekander M. Evidence of fatigue, disordered sleep and peripheral inflammation, but not increased brain TSPO expression, in seasonal allergy: A [(11)C]PBR28 PET study. Brain Behav Immun, 2018, 68:146-157. doi: 10.1016/j.bbi.2017.10.013.

Karshikoff B, Jensen KB, Kosek E, Kalpouzos G, Soop A, Ingvar M, Olgart Höglund C, Lekander M, Axelsson J. Why sickness hurts: A central mechanism for pain induced by peripheral inflammation. Brain Behav Immun, 2016, 57:38-46. doi: 10.1016/j.bbi.2016.04.001.

Karshikoff B, Lekander M, Soop A, Lindstedt F, Ingvar M, Kosek E, Olgart Höglund C, Axelsson J. Modality and sex differences in pain sensitivity during human endotoxemia. Brain Behav Immun, 2015, 46:35-43. doi: 10.1016/j.bbi.2014.11.014.

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Kavelaars Annemieke

Laumet G, Edralin JD, Chiang AC, Dantzer R, Heijnen CJ, Kavelaars A. Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling. Neuropsychopharmacology, 2018. doi: 10.1038/s41386-018-0154-1.

Singhmar P, Huo X, Li Y, Dougherty PM, Mei F, Cheng X, Heijnen CJ, Kavelaars A. Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy. Pain, 2018, 159(5):884-893. doi: 10.1097/j.pain.0000000000001160.

Krukowski K, Ma J, Golonzhka O, Laumet GO, Gutti T, van Duzer JH, Mazitschek R, Jarpe MB, Heijnen CJ, Kavelaars A. HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy. Pain, 2017, 158(6):1126-1137. doi: 10.1097/j.pain.0000000000000893.

Krukowski K, Eijkelkamp N, Laumet G, Hack CE, Li Y, Dougherty PM, Heijnen CJ, Kavelaars A. CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain. J Neurosci, 2016, 36(43):11074-11083. doi: 10.1523/JNEUROSCI.3708-15.2016.

Singhmar P, Huo X, Eijkelkamp N, Berciano SR, Baameur F, Mei FC, Zhu Y, Cheng X, Hawke D, Mayor F Jr, Murga C, Heijnen CJ, Kavelaars A. Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proc Natl Acad Sci U S A, 2016, 113(11):3036-41. doi: 10.1073/pnas.1516036113.

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Khandaker Golam

Khandaker GM, Pearson RM, Zammit S, Lewis G, Jones PB. Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study. JAMA Psychiatry, 2014, 71(10):1121-8. doi: 10.1001/jamapsychiatry.2014.1332.

Kappelmann N, Lewis G, Dantzer R, Jones PB, Khandaker GM. Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Mol Psychiatry, 2018, 23(2):335-343. doi: 10.1038/mp.2016.167.

Khandaker GM, Stochl J, Zammit S, Goodyer I, Lewis G, Jones PB. Childhood inflammatory markers and intelligence as predictors of subsequent persistent depressive symptoms: a longitudinal cohort study. Psychol Med, 2018, 48(9):1514-1522. doi: 10.1017/S0033291717003038.

Khandaker GM, Cousins L, Deakin J, Lennox BR, Yolken R, Jones PB. Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment. Lancet Psychiatry, 2015, 2(3):258-270. doi: 10.1016/S2215-0366(14)00122-9.

Khandaker GM, Dalman C, Kappelmann N, Stochl J, Dal H, Kosidou K, Jones PB, Karlsson H. Association of Childhood Infection With IQ and Adult Nonaffective Psychosis in Swedish Men: A Population-Based Longitudinal Cohort and Co-relative Study. JAMA Psychiatry, 2018, 75(4):356-362. doi: 10.1001/jamapsychiatry.2017.4491.

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Konsman Jan-Pieter

Chaskiel L, Paul F, Gerstberger R, Huebschle T, Konsman JP. Brainstem metabotropic glutamate receptors reduce food intake and activate dorsal pontine and
medullar structures after peripheral bacterial lipopolysaccharide administration. Neuropharmacology, 2016, 107:146-159. doi: 10.1016/j.neuropharm.2016.03.030.

Duclos M, Ouerdani A, Mormed P, Konsman JP. Food restriction-induced hyperactivity: Addiction or adaptation to famine? Psychoneuroendocrinology, 2013, 38(6):884-897. doi: 10.1016/j.psyneuen.2012.09.012.

Pourtau L, Leemburg S, Roux P, Leste-Lassere T, Costaglioli P, Garbet B, Drutel G, Konsman JP. Hormonal, hypothalamic and striatal responses to reduced body weight gain are attenuated in anorectic rats bearing small tumors. Brain Behavior and Immunity, 2011, 25(4):777-786. doi: 10.1016/j.bbi.2011.02.004.

Konsman JP, Veeneman J, Combe C, Luheshi GN, Dantzer R. Central nervous action of interleukin-1 mediates activation of limbic structures and behavioral depression in response to peripheral administration of bacterial lipopolysaccharide. European Journal of Neuroscience, 2008, 28:2499-2510. doi: 10.1111/j.1460-9568.2008.06549.x.

Konsman JP, Vigues S, Mackerlova L, Bristow AF, Blomqvist A. Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: Relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli. Journal of Comparative Neurology, 2004, 472(1): 113-129. doi: 10.1002/cne.20052.

Publication list

 

 

Korte S. Mechiel

Korte-Bouws GAH, van Heesch F, Westphal KGC, Ankersmit LMJ, van Oosten EM, Güntürkün O, Korte SM. Bacterial Lipopolysaccharide Increases Serotonin Metabolism in Both Medial Prefrontal Cortex and Nucleus Accumbens in Male Wild Type Rats, but Not in Serotonin Transporter Knockout Rats. Pharmaceuticals (Basel), 2018,11(3). pii: E66. doi: 10.3390/ph11030066.

Korte SM, Prins J, Krajnc AM, Hendriksen H, Oosting RS, Westphal KG, Korte-Bouws GA, Olivier B. The many different faces of major depression: it is time for personalized medicine. Eur J Pharmacol, 2015, 753:88-104. doi: 10.1016/j.ejphar.2014.11.045.

van Heesch F, Prins J, Konsman JP, Korte-Bouws GA, Westphal KG, Rybka J, Olivier B, Kraneveld AD, Korte SM. Lipopolysaccharide increases degradation of central monoamines: an in vivo microdialysis study in the nucleus accumbens and medial prefrontal cortex of mice. Eur J Pharmacol, 2014, 725:55-63. doi: 10.1016/j.ejphar.2014.01.014.

van Heesch F, Prins J, Konsman JP, Westphal KG, Olivier B, Kraneveld AD, Korte SM. Lipopolysaccharide-induced anhedonia is abolished in male serotonin transporter knockout rats: an intracranial self-stimulation study. Brain Behav Immun, 2013, 29:98-103. doi: 10.1016/j.bbi.2012.12.013

van Heesch F, Prins J, Korte-Bouws GA, Westphal KG, Lemstra S, Olivier B, Kraneveld AD, Korte SM. Systemic tumor necrosis factor-alpha decreases brain stimulation reward and increases metabolites of serotonin and dopamine in the nucleus accumbens of mice. Behav Brain Res, 2013, 253:191-5. doi: 10.1016/j.bbr.2013.07.038.

 

 

Krüger Karsten

Krüger K, Lechtermann A, Fobker M, Völker K, Mooren FC. Exercise induced redistribution of T lymphocytes is regulated by adrenergic mechanisms. Brain, Behavior, and Immunity, 2008, 22(3):324-38. doi: 10.1016/j.bbi.2007.08.008.

Krüger K, Bredehöft J, Mooren FC, Rummel C. Strength and endurance exercise training differently affect COX-2 and mPGESexpression in mouse brain independent of peripheral inflammation. Journal of Applied Physiology, 2016, 121(1):248-54. doi: 10.1152/japplphysiol.00284.2016.

Krüger K, Seimetz S, Ringseis R, Wilhelm J, Pichl A, Couturier A, Eder K, Weissmann N, Mooren FC. Exercise training reverses inflammation and muscle wasting after smoke exposure. The American Journal of Physiology -Regulatory, Integrative and Comparative Physiology, 2018, 314(3): R366-R376. doi: 10.1152/ajpregu.00316.2017.

Ringseis R, Eder K, Mooren FC, Krüger K. Metabolic Signals and Innate Immune Activation in Obesity and Exercise. Exercise Immunology Review, 2015, 21:58-68. PMID: 25825956.

Ringseis R, Mooren FC, Keller J, Couturier A, Wen G, Hirche F, Stangl GI, Eder K, Krüger K. Regular endurance exercise improves the dimished hepatic carnitinestatus in mice fed a high fat diet. Molecular Nutrition and Food Research, 2011, 552: S193-202. doi: 10.1002/mnfr.201100040.

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Lacourt Tamara

Lacourt TE, Vichaya EG, Escalante C, Manzullo EF, Gunn B, Hess KR, Heijnen CJ, Dantzer R. An effort expenditure perspective on cancer-related fatigue. Psychoneuroendocrinology, 2018, 96:109-117. doi: 10.1016/j.psyneuen.2018.06.009.

Lacourt TE, Kavelaars A, Galloway-Peña JR, Sahasrabhojane PV, Shah ND, Futreal A, Kontoyiannis DP, Shelburne SA, Heijnen CJ. Associations of inflammation with symptom burden in patients with acute myeloid leukemia. Psychoneuroendocrinology, 2018, 89:203-208. doi: 10.1016/j.psyneuen.2018.01.018.

Lacourt TE, Houtveen JH, Veldhuijzen van Zanten JJ, Bosch JA, Drayson MT, Van Doornen LJ. Negative affectivity predicts decreased pain tolerance during low-grade inflammation in healthy women. Brain Behav Immun, 2015, 44:32-6. doi: 10.1016/j.bbi.2014.10.003.

Lacourt TE, Vichaya EG, Chiu GS, Dantzer R, Heijnen CJ. The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure. Front Behav Neurosci, 2018, 12:78. doi: 10.3389/fnbeh.2018.00078.

Lacourt TE, Houtveen JH, Doornen LJ, Benson S, Grigoleit JS, Cesko E, Elsenbruch S. Biological and psychological predictors of visceral pain sensitivity in healthy premenopausal women. Eur J Pain, 2014, 18(4):567-74. doi: 10.1002/j.1532-2149.2013.00397.x.

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Lasselin Julie

Lasselin J, Lekander M, Benson S, Schedlowski M, Engler H. Sick for Science: Experimental endotoxemia as a translational tool to develop and test new therapies for inflammation-associated depression. Molecular Psychiatry, 2020. doi: 10.1038/s41380-020-00869-2.

Lasselin J, Schedlowski M, Karshikoff B, Engler H, Lekander M, Konsman JP. Comparison of bacterial lipopolysaccharide-induced sickness behavior in rodents and humans: relevance for symptoms of anxiety and depression. Neurosci Biobehav Rev, 2020, 115:15-24. doi: 10.1016/j.neubiorev.2020.05.001.

Lasselin J, Benson S, Hebebrand J, Boy K, Weskamp V, Handke A, Hasenberg T, Remy M, Föcker M, Unteroberdörster M, Brinkhoff A, Engler H, Schedlowski M. Immunological and behavioral responses to in vivo lipopolysaccharide administration in young and healthy obese and normal-weight humans. Brain Behav Immun, 2020, 88:283-293. doi: 10.1016/j.bbi.2020.05.071.

Lasselin J, Petrovic P, Olsson MJ, Paues-Göranson S, Lekander M, Jensen KB, Axelsson J. Sickness behavior is not all about the immune response: possible roles of expectations and prediction errors in the worry of being sick. Brain, Behavior and Immunity, in press. doi: 10.1016/j.bbi.2018.09.008.

Karshikoff B, Sundelin T, Lasselin J. Role of inflammation in human fatigue: relevance of multidimensional assessments and potential neuronal mechanisms. Frontiers in Immunology, 2017, 8:21. doi: 10.3389/fimmu.2017.00021.

Lasselin J, Treadway MT, Lacourt TE, Soop A, Olsson MJ, Karshikoff B, Paues-Göranson S, Axelsson J, Dantzer R, Lekander M. Lipopolysaccharide alters motivated behavior in a monetary reward task: a randomized trial. Neuropsychopharmacology, 2017, 42(4):801-810. doi: 10.1038/npp.2016.191.

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Laumet Goeffroy

Laumet G, Garriga J, Chen SR, Zhang Y, Li DP, Smith TM, Dong Y, Jelinek J, Cesaroni M, Issa JP, Pan HL. G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition. Nat Neurosci, 2015, 18(12):1746-55. doi: 10.1038/nn.4165.

Krukowski K, Eijkelkamp N, Laumet G, Hack CE, Li Y, Dougherty PM, Heijnen CJ, Kavelaars A. CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain. J Neurosci, 2016, 36(43):11074-11083. doi: 10.1523/JNEUROSCI.3708-15.2016.

Laumet G, Zhou W, Dantzer R, Edralin JD, Huo X, Budac DP, O’Connor JC, Lee AW, Heijnen CJ, Kavelaars A. Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain. Brain Behav Immun, 2017, 66:94-102. doi: 10.1016/j.bbi.2017.07.008.

Laumet G, Edralin JD, Chiang AC, Dantzer R, Heijnen CJ, Kavelaars A. Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling. Neuropsychopharmacology, 2018. doi: 10.1038/s41386-018-0154-1.

Garriga J, Laumet G, Chen SR, Zhang Y, Madzo J, Issa JJ, Pan HL, Jelinek J. Nerve Injury-Induced Chronic Pain Is Associated with Persistent DNA Methylation Reprogramming in Dorsal Root Ganglion. J Neurosci, 2018, 38(27):6090-6101. doi: 10.1523/JNEUROSCI.2616-17.2018.

 

 

Layé Sophie

Bazinet RP, Metherel AH, Chen CT, Shaikh SR, Nadjar A, Joffre C, Layé S. Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression. Brain Behav Immun. 2020 Mar;85:21-28. doi: 10.1016/j.bbi.2019.07.001.

Labrousse VF, Leyrolle Q, Amadieu C, Aubert A, Sere A, Coutureau E, Grégoire S, Bretillon L, Pallet V, Gressens P, Joffre C, Nadjar A, Layé S. Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation. Brain Behav Immun. 2018 Oct;73:427-440. doi: 10.1016/j.bbi.2018.06.004.

Leyrolle Q, Decoeur F, Briere G, Amadieu C, Quadros ARAA, Voytyuk I, Lacabanne C, Benmamar-Badel A, Bourel J, Aubert A, Sere A, Chain F, Schwendimann L, Matrot B, Bourgeois T, Grégoire S, Leblanc JG, De Moreno De Leblanc A, Langella P, Fernandes GR, Bretillon L, Joffre C, Uricaru R, Thebault P, Gressens P, Chatel JM, Layé S*, Nadjar A*. Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime. Neuropsychopharmacology. 2020 Aug 11. doi: 10.1038/s41386-020-00793-7.

Layé S, Nadjar A, Joffre C, Bazinet RP. Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology. Pharmacol Rev. 2018 Jan;70(1):12-38. doi: 10.1124/pr.117.014092.

 

  

Lehto Soili

Kraav SL, Tolmunen T, Kauhanen J, Lehto SM. The difference in chronic inflammation between individuals with officially documented and self-reported adverse childhood experiences is maintained until older middle-age. Psychol Med. 2020 Mar 19:1-3. doi: 10.1017/S0033291720000562

Lahti-Pulkkinen M, Girchenko P, Robinson R, Lehto SM, Toffol E, Heinonen K, Reynolds RM, Kajantie E, Laivuori H, Villa PM, Hämäläinen E, Lahti J, Räikkönen K. Maternal depression and inflammation during pregnancy. Psychol Med. 2019 Aug 23:1-13. doi: 10.1017/S0033291719001909

Ali-Sisto T, Tolmunen T, Viinamäki H, Mäntyselkä P, Valkonen-Korhonen M, Koivumaa-Honkanen H, Honkalampi K, Ruusunen A, Nandania J, Velagapudi V, Lehto SM. Global arginine bioavailability ratio is decreased in patients with major depressive disorder. J Affect Disord. 2018 Mar 15;229:145-151. doi: 10.1016/j.jad.2017.12.030

Sarkar A, Lehto SM, Harty S, Dinan TG, Cryan JF, Burnet PWJ. Psychobiotics and the Manipulation of Bacteria-Gut-Brain Signals. Trends Neurosci. 2016 Nov;39(11):763-781. doi: 10.1016/j.tins.2016.09.002

Elomaa AP, Viinamäki H, Harvima IT, Koivumaa-Honkanen H, Honkalampi K, Valkonen-Korhonen M, Lehto SM. Increased mitogen-stimulated lymphocyte proliferation is associated with the clinical response in major depressive disorder in women: A follow-up study. Psychiatry Res. 2016 May 30;239:220-1. doi: 10.1016/j.psychres.2016.03.026.

 

  

Lekander Mats

Olsson MJ, Lundström JN, Kimball BA, Gordon AR, Karshikoff B, Hosseini N, Sorjonen K, Olgart Höglund C, Solares C, Soop A, Axelsson J, Lekander M. The scent of disease: human body odor contains an early chemosensory cue of sickness. Psychol Sci, 2014, 25(3):817-23. doi: 10.1177/0956797613515681

Lekander M, Karshikoff B, Johansson E, Soop A, Fransson P, Lundström JN, Andreasson A, Ingvar M, Petrovic P, Axelsson J, Nilsonne G. Intrinsic functional connectivity of insular cortex and symptoms of sickness during acute experimental inflammation. Brain Behav Immun, 2016, 56:34-41. doi: 10.1016/j.bbi.2015.12.018

Regenbogen C, Axelsson J, Lasselin J, Porada DK, Sundelin T, Peter MG, Lekander M, Lundström JN, Olsson MJ. Behavioral and neural correlates to multisensory detection of sick humans. Proc Natl Acad Sci U S A, 2017, 114(24):6400-6405. doi: 10.1073/pnas.1617357114

Tamm S, Cervenka S, Forsberg A, Estelius J, Grunewald J, Gyllfors P, Karshikoff B, Kosek E, Lampa J, Lensmar C, Strand V, Akerstedt T, Halldin C, Ingvar M, Olgart Hoglund C, Lekander M. Evidence of fatigue, disordered sleep and peripheral inflammation, but not increased brain TSPO expression, in seasonal allergy: A [11C]PBR28 PET study. Brain Behav Immun, 2018, 68:146-157. doi: 10.1016/j.bbi.2017.10.013

Axelsson J, Sundelin T, Olsson MJ, Sorjonen K, Axelsson C, Lasselin J, Lekander M. Identification of acutely sick people and facial cues of sickness. Proc Biol Sci, 2018, 285(1870), pii: 20172430. doi: 10.1098/rspb.2017.2430.

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Marino Franca

Kustrimovic N, Comi C, Magistrelli L, Rasini E, Legnaro M, Bombelli R, Aleksic I, Blandini F, Minafra B, Riboldazzi G, Sturchio A, Mauri M, Bono G, Marino F, Cosentino M. Parkinson’s disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients. J Neuroinflammation, 2018, 15(1):205. doi: 10.1186/s12974-018-1248-8.

Marino F, Scanzano A, Pulze L, Pinoli M, Rasini E, Luini A, Bombelli R, Legnaro M, de Eguileor M, Cosentino M. β2 -Adrenoceptors inhibit neutrophil extracellular traps in human polymorphonuclear leukocytes. J Leukoc Biol, 2018, 104(3):603-614. doi: 10.1002/JLB.3A1017-398RR.

Cosentino M, Kustrimovic N, Ferrari M, Rasini E, Marino F. cAMP levels in lymphocytes and CD4+ regulatory T-cell functions are affected by dopamine receptor gene polymorphisms. Immunology, 2018, 153(3):337-341. doi: 10.1111/imm.12843.

Pinoli M, Marino F, Cosentino M. Dopaminergic Regulation of Innate Immunity: a Review. J Neuroimmune Pharmacol, 2017, 12(4):602-623. doi: 10.1007/s11481-017-9749-2.

Marino F, Cosentino M. Multiple sclerosis: Repurposing dopaminergic drugs for MS-the evidence mounts. Nat Rev Neurol, 2016, 12(4):191-2. doi: 10.1038/nrneurol.2016.33.
 

  

Miljković Đorđe

Djedovic N, Mansilla MJ, Jevtić B, Navarro-Barriuso J, Saksida T, Martínez-Cáceres EM, Miljković Ð. Ethyl Pyruvate Induces Tolerogenic Dendritic Cells. Front Immunol, 2019, 10:157. doi: 10.3389/fimmu.2019.00157.

Stanisavljević S, Dinić M, Jevtić B, Đedović N, Momčilović M, Đokić J, Golić N, Mostarica Stojković M, Miljković Đ. Gut Microbiota Confers Resistance of Albino Oxford Rats to the Induction of Experimental Autoimmune Encephalomyelitis. Front Immunol, 2018, 9:942. doi: 10.3389/fimmu.2018.00942.

Djedović N, Stanisavljevic S, Jevtić B, Momčilović M, Lavrnja I, Miljković D. Anti-encephalitogenic effects of ethyl pyruvate are reflected in the central nervous system and the gut. Biomed Pharmacother, 2017, 96:78-85. doi: 10.1016/j.biopha.2017.09.110.

Miljković D, Blaževski J, Petković F, Djedović N, Momčilović M, Stanisavljević S, Jevtić B, Mostarica Stojković M, Spasojević I. A comparative analysis of multiple sclerosis-relevant anti-inflammatory properties of ethyl pyruvate and dimethyl fumarate. J Immunol, 2015, 194(6):2493-503. doi: 10.4049/jimmunol.1402302.
 

  

  

Nadjar Agnes

Labrousse VF, Leyrolle Q, Amadieu C, Aubert A, Sere A, Coutureau E, Grégoire S, Bretillon L, Pallet V, Gressens P, Joffre C, Nadjar A, Layé S. Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation. Brain Behav Immun, 2018, 73:427-440. doi: 10.1016/j.bbi.2018.06.004.

Layé S, Nadjar A, Joffre C, Bazinet RP. Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology. Pharmacol Rev, 2018, 70(1):12-38. doi: 10.1124/pr.117.014092.

Delpech JC, Saucisse N, Parkes SL, Lacabanne C, Aubert A, Casenave F, Coutureau E, Sans N, Layé S, Ferreira G, Nadjar A. Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission. J Neurosci, 2015, 35(7):3022-33. doi: 10.1523/JNEUROSCI.3028-14.2015.

Delpech JC, Madore C, Joffre C, Aubert A, Kang JX, Nadjar A, Layé S. Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation. Neuropsychopharmacology, 2015, 40(3):525-36. doi: 10.1038/npp.2014.196.

Nadjar A, Blutstein T, Aubert A, Laye S, Haydon PG. Astrocyte-derived adenosine modulates increased sleep pressure during inflammatory response. Glia, 2013, 61(5):724-31. doi: 10.1002/glia.22465.

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Ricon-Becker Itay

Ricon I, Hanalis-Miller T, Haldar R, Jacoby R, Ben-Eliyahu S. Perioperative biobehavioral interventions to prevent cancer recurrence through combined inhibition of β-adrenergic and cyclooxygenase 2 signaling. Cancer. 2019 Jan 1;125(1):45-56. doi: 10.1002/cncr.31594.

Ricon I, Hiller JG, Ben-Eliyahu S. The Combined Blockade of β-Adrenoceptor and COX-2 During the Perioperative Period to Improve Long-term Cancer Outcomes. Int Anesthesiol Clin. 2016 Fall;54(4):72-91. doi: 10.1097/AIA.0000000000000116.

 

  

Rohleder Nicolas

Thoma MV, Gianferante D, Hanlin L, Fiksdal A, Chen X, Rohleder N. Stronger hypothalamus-pituitary-adrenal axis habituation predicts lesser sensitization of inflammatory response to repeated acute stress exposures in healthy young adults. Brain Behav Immun, 2017, 61:228-235. doi: 10.1016/j.bbi.2016.11.030.

Kuras YI, McInnis CM, Thoma MV, Chen X, Hanlin L, Gianferante D, Rohleder N. Increased alpha-amylase response to an acute psychosocial stress challenge in healthy adults with childhood adversity. Dev Psychobiol, 2017, 59(1):91-98. doi: 10.1002/dev.21470.

McInnis CM, Wang D, Gianferante D, Hanlin L, Chen X, Thoma MV, Rohleder N. Response and habituation of pro- and anti-inflammatory gene expression to repeated acute stress. Brain Behav Immun, 2015, 46:237-48. doi: 10.1016/j.bbi.2015.02.006.

Rohleder N, Marin TJ, Ma R, Miller GE. Biologic cost of caring for a cancer patient: dysregulation of pro- and anti-inflammatory signaling pathways. J Clin Oncol, 2009, 27(18):2909-15. doi: 10.1200/JCO.2008.18.7435.

Rohleder N. Stimulation of systemic low-grade inflammation by psychosocial stress. Psychosom Med, 2014, 76(3):181-9. doi: 10.1097/PSY.0000000000000049.

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Rolls Asya

A Rolls, M Makam, D Kroeger, D Colas, L de Lecea, H Craig Heller. Sleep to Forget: Interference of Fear Memories During Sleep. Mol Psychiatry, 2013, 18(11):1166-70. doi: 10.1038/mp.2013.121.

A Rolls, WW Pang, I Ibarra, D Colas, P Bonnavion, B Korin, HC Heller, IL Weissman, L de Lecea. Sleep Disruption Impairs Haematopoietic Stem Cell Transplantation in Mice. Nat Commun, 2015, 6:8516. doi: 10.1038/ncomms9516.

TL Ben-Shaanan, H Azulay-Debby, T Dubovik, E Starosvetsky, B Korin, M Schiller, NL Green, Y Admon, F Hakim, SS Shen-Orr, A Rolls. Activation of the Reward System Boosts Innate and Adaptive Immunity. Nat Med, 2016, 22(8):940-4. doi: 10.1038/nm.4133

TL Ben-Shaanan, M Schiller, H Azulay-Debby, B Korin, N Boshnak, T Koren, M Krot, J Shakya, MA Rahat, F Hakim, A Rolls. Modulation of Anti-Tumor Immunity by the Brain’s Reward System. Brain Nat Commun, 2018, 9(1):2723. doi: 10.1038/s41467-018-05283-5.

Korin B, Ben-Shaanan TL, Schiller M, Dubovik T, Azulay-Debby H, Boshnak NT, Koren T, Rolls A. High-dimensional, single-cell characterization of the brain’s immune compartment. Nat Neurosci, 2017, 20(9):1300-1309. doi: 10.1038/nn.4610.

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Rummel Christoph

Sonenberg N, Aguilar-Valles A, Haji N, De Gregorio D, Camacho EM, Eslamizade M, Popic J, Sharma V, Cao R, Rummel C, Tanti A, Wiebe S, Nunez N, Comai S, Nadon R, Luheshi G, Mechawar N, Turecki G, Lacaille JC, Gobbi G. Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E. Nat. Commun, 2018, 9: 2459. doi: 10.1038/s41467-018-04883-5.

Koenig S, Bredehöft J, Perniss A, Fuchs F, Roth J and Rummel C. Age dependent hypothalamic and pituitary responses to novel environment stress or lipopolysaccharide in rats. Front. Behav. Neurosci., 2018, 12: 55. doi: 10.3389/fnbeh.2018.00055.

Schneiders J, Fuchs F, Damm J, Herden C, Gerstberger R, Soares DM, Roth J, Rummel C. The transcription factor nuclear factor interleukin 6 mediates pro- and anti-inflammatory responses during LPS-induced systemic inflammation in mice. Brain Behav Immun, 2015, 48: 147-164. doi: 10.1016/j.bbi.2015.03.008

Koenig S, Luheshi GN, Wenz T, Gerstberger R, Roth J, Rummel C. Leptin is involved in age-dependent changes in response to systemic inflammation in the rat. Brain Behav Immun, 2014, 36: 128-38. doi: 10.1016/j.bbi.2013.10.019.

Rummel C, Inoue W, Poole S, and Luheshi GN. Leptin regulates neutrophil recruitment into the brain following severe systemic LPS-induced inflammation. Mol Psychiatry, 2010, 15: 523-34. doi: 10.1038/mp.2009.98.

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Schäfer Martin

Schaefer M, Hinzpeter A, Mohmand A, Janssen G, Pich M, Schwaiger M, Sarkar R, Friebe A, Heinz A, Kluschke M, Ziemer M, Gutsche J, Weich V, Halangk J, Berg T. Hepatitis C treatment in “difficult-to-treat” psychiatric patients with pegylated interferon-alpha and ribavirin: response and psychiatric side effects. Hepatology. 2007 Oct;46(4):991-8. doi: 10.1002/hep.21791.

Heinze S, Egberts F, Rötzer S, Volkenandt M, Tilgen W, Linse R, Boettjer J, Vogt T, Spieth K, Eigentler T, Brockmeyer NH, Hinzpeter A, Hauschild A, Schaefer M. Depressive mood changes and psychiatric symptoms during 12-month low-dose interferon-alpha treatment in patients with malignant melanoma: results from the multicenter DeCOG trial. J Immunother. 2010 Jan;33(1):106-14. doi: 10.1097/CJI.0b013e3181b8bdb9

Schaefer M, Sarkar R, Knop V, Effenberger S, Friebe A, Heinze L, Spengler U, Schlaepfer T, Reimer J, Buggisch P, Ockenga J, Link R, Rentrop M, Weidenbach H, Fromm G, Lieb K, Baumert TF, Heinz A, Discher T, Neumann K, Zeuzem S, Berg T. Escitalopram for the prevention of peginterferon-α2a-associated depression in hepatitis C virus-infected patients without previous psychiatric disease: a randomized trial. Ann Intern Med. 2012 Jul 17;157(2):94-103. doi: 10.7326/0003-4819-157-2-201207170-00006.

Schaefer M, Capuron L, Friebe A, Diez-Quevedo C, Robaeys G, Neri S, Foster GR, Kautz A, Forton D, Pariante CM. Hepatitis C infection, antiviral treatment and mental health: a European expert consensus statement. J Hepatol. 2012 Dec;57(6):1379-90. doi: 10.1016/j.jhep.2012.07.037.

Sarkar S, Sarkar R, Berg T, Schaefer M. Sadness and mild cognitive impairment as predictors for interferon-alpha-induced depression in patients with hepatitis C. Br J Psychiatry. 2015 Jan;206(1):45-51. doi: 10.1192/bjp.bp.113.141770.

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Schoemaker Regien

Tasbihgou SR, Netkova M, Kalmar AF, Doorduin J, Struys MMRF, Schoemaker RG, Absalom AR. Brain changes due to hypoxia during light anaesthesia can be prevented by deepening anaesthesia; a study in rats. PLoS One, 2018, 13(2):e0193062. doi: 10.1371/journal.pone.0193062.

Gouweleeuw L, Hovens IB, van Leeuwen BL, Schoemaker RG. Neutrophil gelatinase-associated lipocalin and microglial activity are associated with distinct postoperative behavioral changes in rats. Behav Brain Res, 2017, 319:104-109. doi: 10.1016/j.bbr.2016.11.023

Gouweleeuw L, Hovens IB, Liu H, Naudé PJW, Schoemaker RG. Differences in the association between behavior and neutrophil gelatinase-associated lipocalin in male and female rats after coronary artery ligation. Physiol Behav, 2016, 163:7-16. doi: 10.1016/j.physbeh.2016.04.040.

Mommersteeg PMC, Schoemaker RG, Naudé PJW, Eisel ULM, Garrelds IM, Schalkwijk CG, Westerhuis BWJJM, Kop WJ, Denollet J. Depression and markers of inflammation as predictors of all-cause mortality in heart failure. Brain Behav Immun, 2016, 57:144-150. doi: 10.1016/j.bbi.2016.03.012.

Hovens IB, Schoemaker RG, van der Zee EA, Absalom AR, Heineman E, van Leeuwen BL. Postoperative cognitive dysfunction: Involvement of neuroinflammation and neuronal functioning. Brain Behav Immun, 2014, 38:202-10. doi: 10.1016/j.bbi.2014.02.002.

 

  

Seiler Annina

Seiler A, Sood AK, Jenewein J, Fagundes CP. Can stress promote the pathophysiology of brain metastases? A critical review of biobehavioral mechanisms. Brain Behav Immun. 2020 Jul;87:860-880. doi: 10.1016/j.bbi.2019.12.013.

 

  

Sindi Shireen

Sindi S, Kåreholt I, Eskelinen M, Hooshmand B, Lehtisalo J, Soininen H, Ngandu T, Kivipelto M. Healthy Dietary Changes in Midlife Are Associated with Reduced Dementia Risk Later in Life. Nutrients. 2018 Nov 3;10(11):1649. doi: 10.3390/nu10111649.

Sindi S, Kåreholt I, Johansson L, Skoog J, Sjöberg L, Wang HX, Johansson B, Fratiglioni L, Soininen H, Solomon A, Skoog I, Kivipelto M. Sleep disturbances and dementia risk: A multicenter study. Alzheimers Dement. 2018 Oct;14(10):1235-1242. doi: 10.1016/j.jalz.2018.05.012.

Sindi S, Johansson L, Skoog J, Mattsson AD, Sjöberg L, Wang HX, Fratiglioni L, Kulmala J, Soininen H, Solomon A, Johansson B, Skoog I, Kivipelto M, Kåreholt I. Sleep disturbances and later cognitive status: a multi-centre study. Sleep Med. 2018 Dec;52:26-33. doi: 10.1016/j.sleep.2017.11.1149.

Sindi S, Kåreholt I, Solomon A, Hooshmand B, Soininen H, Kivipelto M. Midlife work-related stress is associated with late-life cognition. J Neurol. 2017 Sep;264(9):1996-2002. doi: 10.1007/s00415-017-8571-3.

Sindi S, Ngandu T, Hovatta I, Kåreholt I, Antikainen R, Hänninen T, Levälahti E, Laatikainen T, Lindström J, Paajanen T, Peltonen M, Khalsa DS, Wolozin B, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M, Solomon A; FINGER study group. Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial. J Alzheimers Dis. 2017;59(4):1459-1470. doi: 10.3233/JAD-170123.

 

  

Sharshar Tarek

Benghanem S, Mazeraud A, Azabou E, Chhor V, Shinotsuka CR, Claassen J, Rohaut B, Sharshar T. Brainstem dysfunction in critically ill patients. Crit Care, 2020, 24(1):5. doi: 10.1186/s13054-019-2718-9.

Mazeraud A, Righy C, Bouchereau E, Benghanem S, Bozza FA, Sharshar T. Septic-Associated Encephalopathy: a Comprehensive Review. Neurotherapeutics, 2020, 17(2):392-403. doi: 10.1007/s13311-020-00862-1.

Slooter AJC, Otte WM, Devlin JW, Arora RC, Bleck TP, Claassen J, Duprey MS, Ely EW, Kaplan PW, Latronico N, Morandi A, Neufeld KJ, Sharshar T, MacLullich AMJ, Stevens RD. Updated nomenclature of delirium and acute encephalopathy: statement of ten Societies. Intensive Care Med, 2020, 46(5):1020-1022. doi: 10.1007/s00134-019-05907-4.

Azabou E, Rohaut B, Porcher R, Heming N, Kandelman S, Allary J, Moneger G, Faugeras F, Sitt JD, Annane D, Lofaso F, Chrétien F, Mantz J, Naccache L, Sharshar T; GENeR** (Groupe d’Explorations Neurologiques en Réanimation). Mismatch negativity to predict subsequent awakening in deeply sedated critically ill patients. Br J Anaesth, 2018, 121(6):1290-1297. doi: 10.1016/j.bja.2018.06.029.

Annane D, Sharshar T. Cognitive decline after sepsis. Lancet Respir Med, 2015,3(1):61-9. doi: 10.1016/S2213-2600(14)70246-2.

 

  

Straub Rainer H

Straub RH. The brain and immune system prompt energy shortage in chronic inflammation and ageing. Nat Rev Rheumatol, 2017, 13(12):743-751. doi: 10.1038/nrrheum.2017.172

Straub RH, Schradin C. Chronic inflammatory systemic diseases: An evolutionary trade-off between acutely beneficial but chronically harmful programs. Evol Med Public Health, 2016, 2016(1):37-51. doi: 10.1093/emph/eow001.

Straub RH. Rheumatoid arthritis: Stress in RA: a trigger of proinflammatory pathways? Nat Rev Rheumatol. 2014 Sep;10(9):516-8. doi: 10.1038/nrrheum.2014.110.

Klatt S, Stangl H, Kunath J, Lowin T, Pongratz G, Straub RH. Peripheral elimination of the sympathetic nervous system stimulates immunocyte retention in lymph nodes and ameliorates collagen type II arthritis. Brain Behav Immun, 2016, 54:201-210. doi: 10.1016/j.bbi.2016.02.006.

Pongratz G, Straub RH. Role of peripheral nerve fibres in acute and chronic inflammation in arthritis. Nat Rev Rheumatol, 2013, 9(2):117-26. doi: 10.1038/nrrheum.2012.181.

 

  

  

Toft Helge

Toft H, Neupane SP, Bramness JG, Tilden T, Wampold BE, Lien L. The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment. BMC Psychiatry. 2018 Apr 10;18(1):95. doi: 10.1186/s12888-018-1677-z.

Toft H, Bramness JG, Lien L, Abebe DS, Wampold BE, Tilden T, Hestad K, Neupane SP. PTSD patients show increasing cytokine levels during treatment despite reduced psychological distress. Neuropsychiatr Dis Treat. 2018 Sep 17;14:2367-2378. doi: 10.2147/NDT.S173659

Toft H, Lien L, Neupane SP, Abebe DS, Tilden T, Wampold BE, Bramness JG. Cytokine concentrations are related to level of mental distress in inpatients not using anti-inflammatory drugs. Acta Neuropsychiatr. 2020 Feb;32(1):23-31. doi: 10.1017/neu.2019.36.

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van der Schaaf Marieke

Draper A, Koch RM, van der Meer JW, Aj Apps M, Pickkers P, Husain M, van der Schaaf ME. Effort but not Reward Sensitivity is Altered by Acute Sickness Induced by Experimental Endotoxemia in Humans. Neuropsychopharmacology, 2018, 43(5):1107-1118. doi: 10.1038/npp.2017.231

Roerink ME, van der Schaaf ME, Dinarello CA, Knoop H, van der Meer JW. Interleukin-1 as a mediator of fatigue in disease: a narrative review. J Neuroinflammation, 2017, 14(1):16. doi: 10.1186/s12974-017-0796-7

van der Schaaf ME, Roelofs K, de Lange FP, Geurts DEM, van der Meer JWM, Knoop H, Toni I. Fatigue Is Associated With Altered Monitoring and Preparation of Physical Effort in Patients With Chronic Fatigue Syndrome. Biol Psychiatry Cogn Neurosci Neuroimaging, 2018, 3(4):392-404. doi: 10.1016/j.bpsc.2018.01.015

van der Schaaf ME, De Lange FP, Schmits IC, Geurts DEM, Roelofs K, van der Meer JWM, Toni I, Knoop H. Prefrontal Structure Varies as a Function of Pain Symptoms in Chronic Fatigue Syndrome. Biol Psychiatry, 2017, 81(4):358-365. doi: 10.1016/j.biopsych.2016.07.016

van der Schaaf ME, van Schouwenburg MR, Geurts DE, Schellekens AF, Buitelaar JK, Verkes RJ, Cools R. Establishing the dopamine dependency of human striatal signals during reward and punishment reversal learning. Cereb Cortex, 2014, 24(3):633-42. doi: 10.1093/cercor/bhs344

Publication list

 

  

  

Yirmiya Raz

Reshef R, Kudryavitskaya E, Shani-Narkiss H, Isaacson B, Rimmerman N, Mizrahi A, Yirmiya R. The role of microglia and their CX3CR1 signaling in adult neurogenesis in the olfactory bulb. Elife. 2017 Dec 18;6:e30809. doi: 10.7554/eLife.30809

Rimmerman N, Schottlender N, Reshef R, Dan-Goor N, Yirmiya R. The hippocampal transcriptomic signature of stress resilience in mice with microglial fractalkine receptor (CX3CR1) deficiency. Brain Behav Immun. 2017 Mar;61:184-196. doi: 10.1016/j.bbi.2016.11.023

Yirmiya R, Rimmerman N, Reshef R. Depression as a microglial disease. Trends Neurosci. 2015 Oct;38(10):637-658. doi: 10.1016/j.tins.2015.08.001

Reshef R, Kreisel T, Beroukhim Kay D, Yirmiya R. Microglia and their CX3CR1 signaling are involved in hippocampal- but not olfactory bulb-related memory and neurogenesis. Brain Behav Immun. 2014 Oct;41:239-50. doi: 10.1016/j.bbi.2014.04.009

Kreisel T, Frank MG, Licht T, Reshef R, Ben-Menachem-Zidon O, Baratta MV, Maier SF, Yirmiya R. Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol Psychiatry. 2014 Jun;19(6):699-709. doi: 10.1038/mp.2013.155