Selected Publications

Selected publications and link to publication list (when available) of EPN members

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Andreasson Anna

Andreasson A, Wicksell RK, Lodin K, Karshikoff B, Axelsson J, Lekander M. A Global Measure of Sickness Behavior: Development of the Sickness Questionnaire. J Health Psychol, 2016, pii: 1359105316659917. doi: 10.1177/1359105316659917.

Warnoff C, Lekander M, Hemmingsson T, Sorjonen K, Melin B, Andreasson A. Is poor self-rated health associated with low-grade inflammation in 43,110 late adolescent men of the general population? A cross-sectional study. BMJOpen, 2016, 6(4):e009440. doi: 10.1136/bmjopen-2015-009440.

Andreasson A, Schiller H, Åkerstedt T, Berntson E, Kecklund G, Lekander M. Brief report: Contemplate your symptoms and re-evaluate your health. A study on working adults. J Health Psychol, 2017, Jun 1:1359105317715090. doi: 10.1177/1359105317715090.

Lodin K, Lekander M, Syk J, Alving K, Petrovic P, Andreasson A. Longitudinal co-variations between inflammatory cytokines, lung function and patient reported outcomes in patients with asthma. PLoS One, 2017, 12(9):e0185019. doi: 10.1371/journal.pone.0185019.

Lodin K, Lekander M, Syk J, Alving K, Andreasson A. Associations between self-rated health, sickness behaviour and inflammatory markers in primary care patients with allergic
asthma: a longitudinal study. NPJ Prim Care Respir Med, 2017, 27(1):67. doi: 10.1038/s41533-017-0068-0.
 

 

Axelsson John

Axelsson J, Sundelin T, Olsson MJ, Sorjonen K, Axelsson C, Lasselin J, Lekander M. Identification of acutely sick people and facial cues of sickness. Proc Biol Sci, 2018, 285(1870). pii: 20172430. doi: 10.1098/rspb.2017.2430.

Karshikoff B, Jensen KB, Kosek E, Kalpouzos G, Soop A, Ingvar M, Olgart Höglund C, Lekander M, Axelsson J. Why sickness hurts: A central mechanism for pain induced by peripheral inflammation. Brain Behav Immun, 2016, 57:38-46. doi: 10.1016/j.bbi.2016.04.001.

Karshikoff B, Lekander M, Soop A, Lindstedt F, Ingvar M, Kosek E, Olgart Höglund C, Axelsson J. Modality and sex differences in pain sensitivity during human endotoxemia. Brain Behav Immun, 2015, 46:35-43. doi: 10.1016/j.bbi.2014.11.014.

Sundelin T, Karshikoff B, Axelsson E, Höglund CO, Lekander M, Axelsson J. Sick man walking: Perception of health status from body motion. Brain Behav Immun, 2015, 48:53-6. doi: 10.1016/j.bbi.2015.03.007.

Kecklund G, Axelsson J. Health consequences of shift work and insufficient sleep. BMJ, 2016, 355:i5210. doi: 10.1136/bmj.i5210.

Publication list
 

  

  

Ben-Eliyahu Shamgar

Benish M, Bartal I, Goldfarb Y, Levi B, Avraham R, Raz A, Ben-Eliyahu, S. Perioperative use of beta-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis. Ann Surg Oncol, 2008, 15(7):2042-2052. doi: 10.1245/s10434-008-9890-5.

Glasner A, Avraham R, Rosenne E, Benish M, Zmora O, Shemer S, Meiboom H, Ben-Eliyahu S. Improving survival rates in two models of spontaneous postoperative metastasis in mice by combined administration of a beta-adrenergic antagonist and a cyclooxygenase-2 inhibitor. Journal of Immunology, 2010, 184:2449-2457. doi: 10.4049/jimmunol.0903301.

Horowitz M, Neeman E, Sharon E, Ben-Eliyahu S. Exploiting the critical perioperative period to improve long-term cancer outcomes. Nat Rev Clin Oncol, 2015, 4:213-26. doi: 10.1038/nrclinonc.2014.224.

Sorski L, Melamed R, Matzner P, Lavon H, Shaashua L, Rosenne E, Ben-Eliyahu S. Reducing liver metastases of colon cancer in the context of extensive and minor surgeries through beta-adrenoceptors blockade and COX2 inhibition. Brain Behav Immun, 2016, 58:91-98. doi: 10.1016/j.bbi.2016.05.017.

Shaashua L, Shabat-Simon M, Haldar R, Matzner P, Zmora O, Shabtai M, Sharon E, Allweis T, Barshack I, Hayman L, Arevalo J, Ma J, Horowitz M, Cole S, Ben-Eliyahu S. Perioperative COX-2 andβ-adrenergic blockade improves metastatic biomarkers in breast cancer patients in a phase-II randomized trial. Clinical Cancer Research, 2017, 23(16):4651-4661. doi: 10.1158/1078-0432.CCR-17-0152.
 

 

Benros Michael

Benros ME, Nielsen PR, Nordentoft M, Eaton WW, Dalton SO, Mortensen PB. Autoimmune diseases and severe infections as risk factors for schizophrenia: a 30-year population-based register study. Am J Psychiatry. 2011 Dec;168(12):1303-10. doi: 10.1176/appi.ajp.2011.11030516.

Benros ME, Waltoft BL, Nordentoft M, Ostergaard SD, Eaton WW, Krogh J, Mortensen PB. Autoimmune diseases and severe infections as risk factors for mood disorders: a nationwide study. JAMA Psychiatry, 2013, 70(8):812-20. doi: 10.1001/jamapsychiatry.2013.1111.

Köhler O, Benros ME, Nordentoft M, Farkouh ME, Iyengar RL, Mors O, Krogh J. Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trials. JAMA Psychiatry, 2014, 71(12):1381-91. doi: 10.1001/jamapsychiatry.2014.1611.

Benros ME, Trabjerg BB, Meier S, Mattheisen M, Mortensen PB, Mors O, Børglum AD, Hougaard DM, Nørgaard-Pedersen B, Nordentoft M, Agerbo E. Influence of Polygenic Risk Scores on the Association Between Infections and Schizophrenia. Biol Psychiatry, 2016, 80(8):609-16. doi: 10.1016/j.biopsych.2016.04.008.

Orlovska S, Vestergaard CH, Bech BH, Nordentoft M, Vestergaard M, Benros ME. Association of Streptococcal Throat Infection With Mental Disorders: Testing Key Aspects of the PANDAS Hypothesis in a Nationwide Study. JAMA Psychiatry, 2017, 74(7):740-746. doi: 10.1001/jamapsychiatry.2017.0995.

Publication list

 

  

Blomqvist Anders

Blomqvist A, Engblom D. Neural Mechanisms of Inflammation-Induced Fever. Neuroscientist, 2018, 24(4):381-399. doi: 10.1177/1073858418760481

Eskilsson A, Mirrasekhian E, Dufour S, Schwaninger M, Engblom D, Blomqvist A. Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to STAT3-dependent induction of brain endothelial prostaglandin synthesis. J Neurosci, 2014, 34(48):15957-61. doi: 10.1523/JNEUROSCI.3520-14.2014

Engblom D, Saha S, Engström L, Westman M, Audoly LP, Jakobsson PJ, Blomqvist A. Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis. Nat Neurosci, 2003, 6(11):1137-8. doi: 10.1038/nn1137

Engström L, Ruud J, Eskilsson A, Larsson A, Mackerlova L, Kugelberg U, Qian H, Vasilache AM, Larsson P, Engblom D, Sigvardsson M, Jönsson JI, Blomqvist A. Lipopolysaccharide-induced fever depends on prostaglandin E2 production specifically in brain endothelial cells. Endocrinology, 2012, 153(10):4849-61. doi: 10.1210/en.2012-1375

Vasilache AM, Qian H, Blomqvist A. Immune challenge by intraperitoneal administration of lipopolysaccharide directs gene expression in distinct blood-brain barrier cells toward enhanced prostaglandin E(2) signaling. Brain Behav Immun, 2015, 48:31-41. doi: 10.1016/j.bbi.2015.02.003.

Publication list

 

 

  

Capellino Silvia

Capellino S, Cosentino M, Luini A, Bombelli R, Lowin T, Cutolo M, Marino F, Straub RH. Increased expression of dopamine receptors in synovial fibroblasts from patients with rheumatoid arthritis: inhibitory effects of dopamine on interleukin-8 and interleukin-6. Arthritis Rheumatol, 2014, 66(10):2685-93. doi: 10.1002/art.38746.

Capellino S, Weber K, Gelder M, Härle P, Straub RH. First appearance and location of catecholaminergic cells during experimental arthritis and elimination by chemical sympathectomy. Arthritis Rheum, 2012, 64(4):1110-8. doi: 10.1002/art.33431.

Capellino S, Cosentino M, Wolff C, Schmidt M, Grifka J, Straub RH. Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target. Ann Rheum Dis, 2010, 69(10):1853-60. doi: 10.1136/ard.2009.119701.

Straub RH, Grum F, Strauch U, Capellino S, Bataille F, Bleich A, Falk W, Schölmerich J, Obermeier F. Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation. Gut, 2008, 57(7):911-21. doi: 10.1136/gut.2007.125401.

Cutolo M, Capellino S, Sulli A, Serioli B, Secchi ME, Villaggio B, Straub RH. Estrogens and autoimmune diseases. Ann N Y Acad Sci, 2006, 1089:538-47. doi: 10.1196/annals.1386.043.

Publication list
 

  

Cosentino Marco

Kustrimovic N, Comi C, Magistrelli L, Rasini E, Legnaro M, Bombelli R, Aleksic I, Blandini F, Minafra B, Riboldazzi G, Sturchio A, Mauri M, Bono G, Marino F, Cosentino M. Parkinson’s disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients. J Neuroinflammation, 2018, 15(1):205. doi: 10.1186/s12974-018-1248-8.

Marino F, Scanzano A, Pulze L, Pinoli M, Rasini E, Luini A, Bombelli R, Legnaro M, de Eguileor M, Cosentino M. β2 -Adrenoceptors inhibit neutrophil extracellular traps in human polymorphonuclear leukocytes. J Leukoc Biol, 2018, 104(3):603-614. doi: 10.1002/JLB.3A1017-398RR.

Cosentino M, Kustrimovic N, Ferrari M, Rasini E, Marino F. cAMP levels in lymphocytes and CD4+ regulatory T-cell functions are affected by dopamine receptor gene polymorphisms. Immunology, 2018, 153(3):337-341. doi: 10.1111/imm.12843.

Pinoli M, Marino F, Cosentino M. Dopaminergic Regulation of Innate Immunity: a Review. J Neuroimmune Pharmacol, 2017, 12(4):602-623. doi: 10.1007/s11481-017-9749-2.

Marino F, Cosentino M. Multiple sclerosis: Repurposing dopaminergic drugs for MS-the evidence mounts. Nat Rev Neurol, 2016, 12(4):191-2. doi: 10.1038/nrneurol.2016.33.

Publication list
 

  

  

Dantzer Robert

Walker AK, Wing EE, Banks WA, Dantzer R. Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice. Mol Psychiatry, 2018. doi: 10.1038/s41380-018-0076-7.

Lacourt TE, Vichaya EG, Escalante C, Manzullo EF, Gunn B, Hess KR, Heijnen CJ, Dantzer R. An effort expenditure perspective on cancer-related fatigue. Psychoneuroendocrinology, 2018, 96:109-117. doi: 10.1016/j.psyneuen.2018.06.009.

Dantzer R. Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa. Physiol Rev, 2018, 98(1):477-504. doi: 10.1152/physrev.00039.2016.

Grossberg AJ, Vichaya EG, Christian DL, Molkentine JM, Vermeer DW, Gross PS, Vermeer PD, Lee JH, Dantzer R. Tumor-Associated Fatigue in Cancer Patients Develops Independently of IL1 Signaling. Cancer Res, 2018, 78(3):695-705. doi: 1158/0008-5472.CAN-17-2168.

VichayaEG, Laumet G, Christian DL, Grossberg AJ, Estrada DJ, Heijnen CJ, Kavelaars A, Dantzer R. Motivational changes that develop in a mouse model of inflammation-induced depression are independent of indoleamine 2,3 dioxygenase. Neuropsychopharmacology, 2018. doi: 10.1038/s41386-018-0075-z.

 

  

de Punder Karin

de Punder K, Entringer S, Heim C, Deuter CE, Otte C, Wingenfeld K, Kuehl LK. Inflammatory Measures in Depressed Patients With and Without a History of Adverse Childhood Experiences. Front Psychiatry, 2018, 9:610. doi: 10.3389/fpsyt.2018.00610

de Punder K, Heim C, Wadhwa PD, Entringer S. Stress and immunosenescence: The role of telomerase. Psychoneuroendocrinology, 2018, 101:87-100. doi: 10.1016/j.psyneuen.2018.10.019

Entringer S, de Punder K, Buss C, Wadhwa PD. The fetal programming of telomere biology hypothesis: an update. Philos Trans R Soc Lond B Biol Sci, 2018, 373(1741), pii: 20170151. doi: 10.1098/rstb.2017.0151

de Punder K, Heim C, Przesdzing I, Wadhwa PD, Entringer S. Characterization in humans of in vitro leucocyte maximal telomerase activity capacity and association with stress. Philos Trans R Soc Lond B Biol Sci, 2018, 373(1741), pii: 20160441. doi: 10.1098/rstb.2016.0441

de Punder K, Pruimboom L. Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability. Front Immunol, 2015, 6:223. doi: 10.3389/fimmu.2015.00223

Publication list

 

  

  

Eisel Ulrich

Dong Y, Fischer R, Naudé PJ, Maier O, Nyakas C, Duffey M, Van der Zee EA, Dekens D, Douwenga W, Herrmann A, Guenzi E, Kontermann RE, Pfizenmaier K, Eisel UL. Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration. Proc Natl Acad Sci U S A, 2016, 113(43):12304-12309. doi: 10.1073/pnas.1605195113.

Ostroveanu A, van der Zee EA, Eisel UL, Schmidt M, Nijholt IM. Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval. Hippocampus, 2010, 20(9):1018-26. doi: 10.1002/hipo.20700.

Marchetti L, Klein M, Schlett K, Pfizenmaier K, Eisel UL. Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway. J Biol Chem, 2004, 279(31):32869-81. doi: 10.1074/jbc.M311766200.

Williams SK, Fairless R, Maier O, Liermann PC, Pichi K, Fischer R, Eisel ULM, Kontermann R, Herrmann A, Weksler B, Romero N, Couraud PO, Pfizenmaier K, Diem R. Anti-TNFR1 targeting in humanized mice ameliorates disease in a model of multiple sclerosis. Sci Rep, 2018, 8(1):13628. doi: 10.1038/s41598-018-31957-7.

Blank T, Detje CN, Spieß A, Hagemeyer N, Brendecke SM, Wolfart J, Staszewski O, Zöller T, Papageorgiou I, Schneider J, Paricio-Montesinos R, Eisel UL, Manahan-Vaughan D, Jansen S, Lienenklaus S, Lu B, Imai Y, Müller M, Goelz SE, Baker DP, Schwaninger M, Kann O, Heikenwalder M, Kalinke U, Prinz M. Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment. Immunity, 2016, 44(4):901-12. doi: 10.1016/j.immuni.2016.04.005.

Publication list
 

  

Elsenbruch Sigrid

Benson S, Kattoor J, Wegner A, Hammes F, Reidick D, Grigoleit JS, Engler H, Oberbeck R, Schedlowski M, Elsenbruch S. Acute experimental endotoxemia induces visceral hypersensitivity and altered pain evaluation in healthy humans. Pain, 2012, 153(4):794-9. doi: 10.1016/j.pain.2011.12.001.

Benson S, Rebernik L, Wegner A, Kleine-Borgmann J, Engler H1, Schlamann M, Forsting M, Schedlowski M, Elsenbruch S. Neural circuitry mediating inflammation-induced central pain amplification in human experimental endotoxemia. Brain Behav Immun, 2015, 48:222-31. doi: 10.1016/j.bbi.2015.03.017.

Engler H, Benson S, Wegner A, Spreitzer I, Schedlowski M, Elsenbruch S. Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms. Brain Behav Immun, 2016, 52:18-26. doi: 10.1016/j.bbi.2015.08.013.

Benson S, Engler H, Wegner A, Rebernik L, Spreitzer I, Schedlowski M, Elsenbruch S. What Makes You Feel Sick After Inflammation? Predictors of Acute and Persisting Physical Sickness Symptoms Induced by Experimental Endotoxemia. Clin Pharmacol Ther, 2017, 102(1):141-151. doi: 10.1002/cpt.618.

Benson S, Brinkhoff A, Lueg L, Roderigo T, Kribben A, Wilde B, Witzke O, Engler H, Schedlowski M, Elsenbruch S. Effects of acute systemic inflammation on the interplay between sad mood and affective cognition. Transl Psychiatry, 2017, 7(12):1281. doi: 10.1038/s41398-017-0043-0.
 

 

Engler Harald

Engler H, Brendt P, Wischermann J, Wegner A, Röhling R, Schoemberg T, Meyer U, Gold R, Peters J, Benson S, Schedlowski M. Selective increase of cerebrospinal fluid IL-6 during experimental systemic inflammation in humans: association with depressive symptoms. Mol Psychiatry, 2017, 22:1448-1454. doi: 10.1038/mp.2016.264.

Giovanoli S, Weber-Stadlbauer U, Schedlowski M, Meyer U, Engler H. Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies. Brain Behav Immun, 2016, 55:25-38. doi: 10.1016/j.bbi.2015.09.015.

Engler H, Benson S, Wegner A, Spreitzer I, Schedlowski M, Elsenbruch S. Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms. Brain Behav Immun, 2016, 52:18-26. doi: 10.1016/j.bbi.2015.08.013.

Giovanoli S, Engler H, Engler A, Richetto J, Voget M, Willi R, Winter C, Riva MA, Mortensen PB, Feldon J, Schedlowski M, Meyer U. Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice. Science, 2013, 339:1095-1099. doi: 10.1126/science.1228261.

Engler H, Doenlen R, Engler A, Riether C, Prager G, Niemi MB, Pacheco-López G, Krügel U, Schedlowski M. Acute amygdaloid response to systemic inflammation. Brain Behav Immun, 2011, 25:1384-1392. doi: 10.1016/j.bbi.2011.04.005.
 

 

  

Fetissov Sergueï

Fetissov SO. Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour. Nat Rev Endocrinol, 2017, 13:11-25. doi: 10.1038/nrendo.2016.150.

Værøy H, Adori C, Legrand R, Lucas N, Breton J, Cottard C, do Rego JC, Duparc C, Louiset E, Lefebvre H, Déchelotte P, Western E, Andersson S, Hökfelt T, Fetissov SO. Autoantibodies reactive to adrenocorticotropic hormone can alter cortisol secretion in both aggressive and nonaggressive humans. Proc Natl Acad Sci USA, 2018, 115:E6576-E6584. doi: 10.1073/pnas.1720008115.

Lucas N, Legrand R, Bôle-Feysot C, Breton J, Coëffier M, Akkermann K, Järv A, Harro J, Déchelotte P, Fetissov SO. Immunoglobulin G modulation of the melanocortin 4 receptor signaling in obesity and eating disorders. Translational Psychiatry, 2019, 9(1):87. doi: 10.1038/s41398-019-0422-9.

Legrand R, Lucas N, Breton J, Déchelotte P, Fetissov SO. Dopamine release in the lateral hypothalamus is stimulated by α-MSH in both the anticipatory and consummatory phases of feeding. Psychoneuroendocrinology, 2015, 56:79-87. doi: 10.1016/j.psyneuen.2015.02.020.

Tennoune N, Chan P, Breton J, Legrand R, Chabane YN, Akkermann K, Jarv A, Ouelaa W, Takagi K, Ghouzali I, François M, Lucas N, Bole-Feysot C, Pestel-Caron M, do Rego JC, Vaudry D, Harro J, Dé E, Déchelotte P, Fetissov SO. Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide [alpha]-MSH, at the origin of eating disorders. Transl Psychiatry, 2014, 4:e458. doi: 10.1038/tp.2014.98.

 

 

  

Grigoleit Jan Sebastian

Bhattacharya A, Lord B, Grigoleit JS, He Y, Fraser I, Campbell SN, Taylor N, Aluisio L, O’Connor JC, Papp M, Chrovian C, Carruthers N, Lovenberg TW, Letavic MA. Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia. Neuropsychopharmacology, 2018, 43(13):2586-2596. doi: 10.1038/s41386-018-0141-6.

Serrats J, Grigoleit JS, Alvarez-Salas E, Sawchenko PE. Pro-inflammatory immune-to-brain signaling is involved in neuroendocrine responses to acute emotional stress. Brain Behav Immun, 2017, 62:53-63. doi: 10.1016/j.bbi.2017.02.003.

Lasselin J, Alvarez-Salas E, Grigoleit JS. Well-being and immune response: a multi-system perspective. Curr Opin Pharmacol, 2016, 29:34-41. doi: 10.1016/j.coph.2016.05.003.

Schedlowski M, Engler H, Grigoleit JS. Endotoxin-induced experimental systemic inflammation in humans: a model to disentangle immune-to-brain communication. Brain Behav Immun, 2014, 35:1-8. doi: 10.1016/j.bbi.2013.09.015.

Grigoleit JS, Kullmann JS, Wolf OT, Hammes F, Wegner A, Jablonowski S, Engler H, Gizewski E, Oberbeck R, Schedlowski M. Dose-dependent effects of endotoxin on neurobehavioral functions in humans. PLoS One, 2011, 6(12):e28330. doi: 10.1371/journal.pone.0028330.

Publication list

 

  

Hadamitzky Martin

Hadamitzky M, Herring A, Kirchhof J, Bendix I, Haight MJ, Keyvani K, Luckemann L, Unteroberdorster M, Schedlowski M. Repeated Systemic Treatment with Rapamycin Affects Behavior and Amygdala Protein Expression in Rats. Int J Neuropsychopharmacol, 2018, 21:592-602. doi: 10.1093/ijnp/pyy017.

Lückemann L, Unteroberdorster M, Kirchhof J, Schedlowski M, Hadamitzky M. Applications and limitations of behaviorally conditioned immunopharmacological responses. Neurobiol Learn Mem, 2017, 142:91-98. doi: 10.1016/j.nlm.2017.02.012.

Hadamitzky M, Bosche K, Wirth T, Buck B, Beetz O, Christians U, Schniedewind B, Luckemann L, Gunturkun O, Engler H, Schedlowski M. Memory-updating abrogates extinction of learned immunosuppression. Brain Behav Immun, 2016, 52:40-48. doi: 10.1016/j.bbi.2015.09.009.

Lückemann L, Bosche K, Engler H, Schwitalla JC, Hadamitzky M, Schedlowski M. Preexposure to the unconditioned or conditioned stimulus does not affect learned immunosuppression in rats. Brain Behav Immun, 2016, 51:252-257. doi: 10.1016/j.bbi.2015.09.005.

Bosche K, Weissenborn K, Christians U, Witzke O, Engler H, Schedlowski M, Hadamitzky M. Neurobehavioral consequences of small molecule-drug immunosuppression. Neuropharmacology, 2015, 96:83-93. doi: 10.1016/j.neuropharm.2014.12.008.
 

  

Harrison Neil

Harrison NA, Cooper E, Dowell NG, Keramida G, Voon V, Critchley HD, Cercignani M. Quantitative Magnetization Transfer Imaging as a Biomarker for Effects of Systemic Inflammation on the Brain. Biol Psychiatry, 2015, 78(1):49-57. doi: 10.1016/j.biopsych.2014.09.023.

Harrison NA, Voon V, Cercignani M, Cooper EA, Pessiglione M, Critchley HD. A Neurocomputational Account of How Inflammation Enhances Sensitivity to Punishments Versus Rewards. Biol Psychiatry, 2016, 80(1):73-81. doi: 10.1016/j.biopsych.2015.07.018.

Harrison NA, Brydon L, Walker C, Gray MA, Steptoe A, Dolan RJ, Critchley HD. Neural origins of human sickness in interoceptive responses to inflammation. Biol Psychiatry, 2009, 66(5):415-22. doi: 10.1016/j.biopsych.2009.03.007.

Harrison NA, Brydon L, Walker C, Gray MA, Steptoe A, Critchley HD. Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biol Psychiatry, 2009, 66(5):407-14. doi: 10.1016/j.biopsych.2009.03.015.

Harrison NA. Brain Structures Implicated in Inflammation-Associated Depression. Curr Top Behav Neurosci, 2017, 31:221-248. doi: 10.1007/7854_2016_30.

Publication list

 

 

  

Ivanovska Mariya

Vasileva LV, Saracheva KЕ, Ivanovska MV, Petrova AP, Sucouglu E, Murdjeva MA, Getova-Spasova DP. Beneficial Effect of Chronic Treatment with Extracts from Rhodiola Rosea L. and Curcuma Longa L. on the Immunoreactivity of Animals Subjected to a Chronic Mild Stress Model. Folia Med (Plovdiv), 2017, 59(4):443-453. doi: 10.1515/folmed-2017-0046

Sokolova RN, Yankova RK, Abadjieva TI, Popova TA, Ivanovska MV, Murdjeva MA, Orbetzova MM, Dermendzhiev SM, Pavlova MV. Association between Type 2 Diabetes, Obesity and Key Immunological Components of IgE-mediated Inflammation. Folia Med (Plovdiv), 2017, 59(2):159-164. doi: 10.1515/folmed-2017-0021

Vasileva LV, Saracheva KE, Ivanovska MV, Petrova AP, Marchev AS, Georgiev MI, Murdjeva MA, Getova DP. Antidepressant-like effect of salidroside and curcumin on the immunoreactivity of rats subjected to a chronic mild stress model. Food Chem Toxicol, 2018, 121:604-611. doi: 10.1016/j.fct.2018.09.065

Publication list

 

 

  

Karshikoff Bianka

Lasselin J, Lekander M, Axelsson J, Karshikoff B. Sex differences in how inflammation affects behavior: What we can learn from experimental inflammatory models in humans. Front Neuroendocrinol, 2018, pii: S0091-3022(18)30047-5. doi: 10.1016/j.yfrne.2018.06.005.

Andreasson A, Wicksell RK, Lodin K, Karshikoff B, Axelsson J, Lekander M. A global measure of sickness behaviour: Development of the Sickness Questionnaire. J Health Psychol, 2018, 23(11):1452-1463. doi: 10.1177/1359105316659917.

Tamm S, Cervenka S, Forsberg A, Estelius J, Grunewald J, Gyllfors P, Karshikoff B, Kosek E, Lampa J, Lensmar C, Strand V, Åkerstedt T, Halldin C, Ingvar M, Olgart Höglund C, Lekander M. Evidence of fatigue, disordered sleep and peripheral inflammation, but not increased brain TSPO expression, in seasonal allergy: A [(11)C]PBR28 PET study. Brain Behav Immun, 2018, 68:146-157. doi: 10.1016/j.bbi.2017.10.013.

Karshikoff B, Jensen KB, Kosek E, Kalpouzos G, Soop A, Ingvar M, Olgart Höglund C, Lekander M, Axelsson J. Why sickness hurts: A central mechanism for pain induced by peripheral inflammation. Brain Behav Immun, 2016, 57:38-46. doi: 10.1016/j.bbi.2016.04.001.

Karshikoff B, Lekander M, Soop A, Lindstedt F, Ingvar M, Kosek E, Olgart Höglund C, Axelsson J. Modality and sex differences in pain sensitivity during human endotoxemia. Brain Behav Immun, 2015, 46:35-43. doi: 10.1016/j.bbi.2014.11.014.

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Kavelaars Annemieke

Laumet G, Edralin JD, Chiang AC, Dantzer R, Heijnen CJ, Kavelaars A. Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling. Neuropsychopharmacology, 2018. doi: 10.1038/s41386-018-0154-1.

Singhmar P, Huo X, Li Y, Dougherty PM, Mei F, Cheng X, Heijnen CJ, Kavelaars A. Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy. Pain, 2018, 159(5):884-893. doi: 10.1097/j.pain.0000000000001160.

Krukowski K, Ma J, Golonzhka O, Laumet GO, Gutti T, van Duzer JH, Mazitschek R, Jarpe MB, Heijnen CJ, Kavelaars A. HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy. Pain, 2017, 158(6):1126-1137. doi: 10.1097/j.pain.0000000000000893.

Krukowski K, Eijkelkamp N, Laumet G, Hack CE, Li Y, Dougherty PM, Heijnen CJ, Kavelaars A. CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain. J Neurosci, 2016, 36(43):11074-11083. doi: 10.1523/JNEUROSCI.3708-15.2016.

Singhmar P, Huo X, Eijkelkamp N, Berciano SR, Baameur F, Mei FC, Zhu Y, Cheng X, Hawke D, Mayor F Jr, Murga C, Heijnen CJ, Kavelaars A. Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proc Natl Acad Sci U S A, 2016, 113(11):3036-41. doi: 10.1073/pnas.1516036113.

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Khandaker Golam

Khandaker GM, Pearson RM, Zammit S, Lewis G, Jones PB. Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study. JAMA Psychiatry, 2014, 71(10):1121-8. doi: 10.1001/jamapsychiatry.2014.1332.

Kappelmann N, Lewis G, Dantzer R, Jones PB, Khandaker GM. Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Mol Psychiatry, 2018, 23(2):335-343. doi: 10.1038/mp.2016.167.

Khandaker GM, Stochl J, Zammit S, Goodyer I, Lewis G, Jones PB. Childhood inflammatory markers and intelligence as predictors of subsequent persistent depressive symptoms: a longitudinal cohort study. Psychol Med, 2018, 48(9):1514-1522. doi: 10.1017/S0033291717003038.

Khandaker GM, Cousins L, Deakin J, Lennox BR, Yolken R, Jones PB. Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment. Lancet Psychiatry, 2015, 2(3):258-270. doi: 10.1016/S2215-0366(14)00122-9.

Khandaker GM, Dalman C, Kappelmann N, Stochl J, Dal H, Kosidou K, Jones PB, Karlsson H. Association of Childhood Infection With IQ and Adult Nonaffective Psychosis in Swedish Men: A Population-Based Longitudinal Cohort and Co-relative Study. JAMA Psychiatry, 2018, 75(4):356-362. doi: 10.1001/jamapsychiatry.2017.4491.

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Konsman Jan-Pieter

Chaskiel L, Paul F, Gerstberger R, Huebschle T, Konsman JP. Brainstem metabotropic glutamate receptors reduce food intake and activate dorsal pontine and
medullar structures after peripheral bacterial lipopolysaccharide administration. Neuropharmacology, 2016, 107:146-159. doi: 10.1016/j.neuropharm.2016.03.030.

Duclos M, Ouerdani A, Mormed P, Konsman JP. Food restriction-induced hyperactivity: Addiction or adaptation to famine? Psychoneuroendocrinology, 2013, 38(6):884-897. doi: 10.1016/j.psyneuen.2012.09.012.

Pourtau L, Leemburg S, Roux P, Leste-Lassere T, Costaglioli P, Garbet B, Drutel G, Konsman JP. Hormonal, hypothalamic and striatal responses to reduced body weight gain are attenuated in anorectic rats bearing small tumors. Brain Behavior and Immunity, 2011, 25(4):777-786. doi: 10.1016/j.bbi.2011.02.004.

Konsman JP, Veeneman J, Combe C, Luheshi GN, Dantzer R. Central nervous action of interleukin-1 mediates activation of limbic structures and behavioral depression in response to peripheral administration of bacterial lipopolysaccharide. European Journal of Neuroscience, 2008, 28:2499-2510. doi: 10.1111/j.1460-9568.2008.06549.x.

Konsman JP, Vigues S, Mackerlova L, Bristow AF, Blomqvist A. Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: Relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli. Journal of Comparative Neurology, 2004, 472(1): 113-129. doi: 10.1002/cne.20052.

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Korte S. Mechiel

Korte-Bouws GAH, van Heesch F, Westphal KGC, Ankersmit LMJ, van Oosten EM, Güntürkün O, Korte SM. Bacterial Lipopolysaccharide Increases Serotonin Metabolism in Both Medial Prefrontal Cortex and Nucleus Accumbens in Male Wild Type Rats, but Not in Serotonin Transporter Knockout Rats. Pharmaceuticals (Basel), 2018,11(3). pii: E66. doi: 10.3390/ph11030066.

Korte SM, Prins J, Krajnc AM, Hendriksen H, Oosting RS, Westphal KG, Korte-Bouws GA, Olivier B. The many different faces of major depression: it is time for personalized medicine. Eur J Pharmacol, 2015, 753:88-104. doi: 10.1016/j.ejphar.2014.11.045.

van Heesch F, Prins J, Konsman JP, Korte-Bouws GA, Westphal KG, Rybka J, Olivier B, Kraneveld AD, Korte SM. Lipopolysaccharide increases degradation of central monoamines: an in vivo microdialysis study in the nucleus accumbens and medial prefrontal cortex of mice. Eur J Pharmacol, 2014, 725:55-63. doi: 10.1016/j.ejphar.2014.01.014.

van Heesch F, Prins J, Konsman JP, Westphal KG, Olivier B, Kraneveld AD, Korte SM. Lipopolysaccharide-induced anhedonia is abolished in male serotonin transporter knockout rats: an intracranial self-stimulation study. Brain Behav Immun, 2013, 29:98-103. doi: 10.1016/j.bbi.2012.12.013

van Heesch F, Prins J, Korte-Bouws GA, Westphal KG, Lemstra S, Olivier B, Kraneveld AD, Korte SM. Systemic tumor necrosis factor-alpha decreases brain stimulation reward and increases metabolites of serotonin and dopamine in the nucleus accumbens of mice. Behav Brain Res, 2013, 253:191-5. doi: 10.1016/j.bbr.2013.07.038.

 

 

Krüger Karsten

Krüger K, Lechtermann A, Fobker M, Völker K, Mooren FC. Exercise induced redistribution of T lymphocytes is regulated by adrenergic mechanisms. Brain, Behavior, and Immunity, 2008, 22(3):324-38. doi: 10.1016/j.bbi.2007.08.008.

Krüger K, Bredehöft J, Mooren FC, Rummel C. Strength and endurance exercise training differently affect COX-2 and mPGESexpression in mouse brain independent of peripheral inflammation. Journal of Applied Physiology, 2016, 121(1):248-54. doi: 10.1152/japplphysiol.00284.2016.

Krüger K, Seimetz S, Ringseis R, Wilhelm J, Pichl A, Couturier A, Eder K, Weissmann N, Mooren FC. Exercise training reverses inflammation and muscle wasting after smoke exposure. The American Journal of Physiology -Regulatory, Integrative and Comparative Physiology, 2018, 314(3): R366-R376. doi: 10.1152/ajpregu.00316.2017.

Ringseis R, Eder K, Mooren FC, Krüger K. Metabolic Signals and Innate Immune Activation in Obesity and Exercise. Exercise Immunology Review, 2015, 21:58-68. PMID: 25825956.

Ringseis R, Mooren FC, Keller J, Couturier A, Wen G, Hirche F, Stangl GI, Eder K, Krüger K. Regular endurance exercise improves the dimished hepatic carnitinestatus in mice fed a high fat diet. Molecular Nutrition and Food Research, 2011, 552: S193-202. doi: 10.1002/mnfr.201100040.

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Lacourt Tamara

Lacourt TE, Vichaya EG, Escalante C, Manzullo EF, Gunn B, Hess KR, Heijnen CJ, Dantzer R. An effort expenditure perspective on cancer-related fatigue. Psychoneuroendocrinology, 2018, 96:109-117. doi: 10.1016/j.psyneuen.2018.06.009.

Lacourt TE, Kavelaars A, Galloway-Peña JR, Sahasrabhojane PV, Shah ND, Futreal A, Kontoyiannis DP, Shelburne SA, Heijnen CJ. Associations of inflammation with symptom burden in patients with acute myeloid leukemia. Psychoneuroendocrinology, 2018, 89:203-208. doi: 10.1016/j.psyneuen.2018.01.018.

Lacourt TE, Houtveen JH, Veldhuijzen van Zanten JJ, Bosch JA, Drayson MT, Van Doornen LJ. Negative affectivity predicts decreased pain tolerance during low-grade inflammation in healthy women. Brain Behav Immun, 2015, 44:32-6. doi: 10.1016/j.bbi.2014.10.003.

Lacourt TE, Vichaya EG, Chiu GS, Dantzer R, Heijnen CJ. The High Costs of Low-Grade Inflammation: Persistent Fatigue as a Consequence of Reduced Cellular-Energy Availability and Non-adaptive Energy Expenditure. Front Behav Neurosci, 2018, 12:78. doi: 10.3389/fnbeh.2018.00078.

Lacourt TE, Houtveen JH, Doornen LJ, Benson S, Grigoleit JS, Cesko E, Elsenbruch S. Biological and psychological predictors of visceral pain sensitivity in healthy premenopausal women. Eur J Pain, 2014, 18(4):567-74. doi: 10.1002/j.1532-2149.2013.00397.x.

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Lasselin Julie

Lasselin J, Petrovic P, Olsson MJ, Paues-Göranson S, Lekander M, Jensen KB, Axelsson J. Sickness behavior is not all about the immune response: possible roles of expectations and prediction errors in the worry of being sick. Brain, Behavior and Immunity, in press. doi: 10.1016/j.bbi.2018.09.008.

Lasselin J, Lekander M, Paues-Göranson S, Olsson MJ, Axelsson J. Communication of Health in Experimentally Sick Men and Women: a Pilot Study. Psychoneuroendocrinology, 2018, 87:188-195. doi: 10.1016/j.psyneuen.2017.10.024.

Karshikoff B, Sundelin T, Lasselin J. Role of inflammation in human fatigue: relevance of multidimensional assessments and potential neuronal mechanisms. Frontiers in Immunology, 2017, 8:21. doi: 10.3389/fimmu.2017.00021.

Lasselin J, Treadway MT, Lacourt TE, Soop A, Olsson MJ, Karshikoff B, Paues-Göranson S, Axelsson J, Dantzer R, Lekander M. Lipopolysaccharide alters motivated behavior in a monetary reward task: a randomized trial. Neuropsychopharmacology, 2017, 42(4):801-810. doi: 10.1038/npp.2016.191.

Capuron L, Lasselin J, Castanon N. Role of adiposity-driven inflammation in depressive morbidity. Neuropsychopharmacology, 2017, 42(1):115-128. doi: 10.1038/npp.2016.123.

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Laumet Goeffroy

Laumet G, Garriga J, Chen SR, Zhang Y, Li DP, Smith TM, Dong Y, Jelinek J, Cesaroni M, Issa JP, Pan HL. G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition. Nat Neurosci, 2015, 18(12):1746-55. doi: 10.1038/nn.4165.

Krukowski K, Eijkelkamp N, Laumet G, Hack CE, Li Y, Dougherty PM, Heijnen CJ, Kavelaars A. CD8+ T Cells and Endogenous IL-10 Are Required for Resolution of Chemotherapy-Induced Neuropathic Pain. J Neurosci, 2016, 36(43):11074-11083. doi: 10.1523/JNEUROSCI.3708-15.2016.

Laumet G, Zhou W, Dantzer R, Edralin JD, Huo X, Budac DP, O’Connor JC, Lee AW, Heijnen CJ, Kavelaars A. Upregulation of neuronal kynurenine 3-monooxygenase mediates depression-like behavior in a mouse model of neuropathic pain. Brain Behav Immun, 2017, 66:94-102. doi: 10.1016/j.bbi.2017.07.008.

Laumet G, Edralin JD, Chiang AC, Dantzer R, Heijnen CJ, Kavelaars A. Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling. Neuropsychopharmacology, 2018. doi: 10.1038/s41386-018-0154-1.

Garriga J, Laumet G, Chen SR, Zhang Y, Madzo J, Issa JJ, Pan HL, Jelinek J. Nerve Injury-Induced Chronic Pain Is Associated with Persistent DNA Methylation Reprogramming in Dorsal Root Ganglion. J Neurosci, 2018, 38(27):6090-6101. doi: 10.1523/JNEUROSCI.2616-17.2018.

 

  

Lekander Mats

Olsson MJ, Lundström JN, Kimball BA, Gordon AR, Karshikoff B, Hosseini N, Sorjonen K, Olgart Höglund C, Solares C, Soop A, Axelsson J, Lekander M. The scent of disease: human body odor contains an early chemosensory cue of sickness. Psychol Sci, 2014, 25(3):817-23. doi: 10.1177/0956797613515681

Lekander M, Karshikoff B, Johansson E, Soop A, Fransson P, Lundström JN, Andreasson A, Ingvar M, Petrovic P, Axelsson J, Nilsonne G. Intrinsic functional connectivity of insular cortex and symptoms of sickness during acute experimental inflammation. Brain Behav Immun, 2016, 56:34-41. doi: 10.1016/j.bbi.2015.12.018

Regenbogen C, Axelsson J, Lasselin J, Porada DK, Sundelin T, Peter MG, Lekander M, Lundström JN, Olsson MJ. Behavioral and neural correlates to multisensory detection of sick humans. Proc Natl Acad Sci U S A, 2017, 114(24):6400-6405. doi: 10.1073/pnas.1617357114

Tamm S, Cervenka S, Forsberg A, Estelius J, Grunewald J, Gyllfors P, Karshikoff B, Kosek E, Lampa J, Lensmar C, Strand V, Akerstedt T, Halldin C, Ingvar M, Olgart Hoglund C, Lekander M. Evidence of fatigue, disordered sleep and peripheral inflammation, but not increased brain TSPO expression, in seasonal allergy: A [11C]PBR28 PET study. Brain Behav Immun, 2018, 68:146-157. doi: 10.1016/j.bbi.2017.10.013

Axelsson J, Sundelin T, Olsson MJ, Sorjonen K, Axelsson C, Lasselin J, Lekander M. Identification of acutely sick people and facial cues of sickness. Proc Biol Sci, 2018, 285(1870), pii: 20172430. doi: 10.1098/rspb.2017.2430.

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Marino Franca

Kustrimovic N, Comi C, Magistrelli L, Rasini E, Legnaro M, Bombelli R, Aleksic I, Blandini F, Minafra B, Riboldazzi G, Sturchio A, Mauri M, Bono G, Marino F, Cosentino M. Parkinson’s disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients. J Neuroinflammation, 2018, 15(1):205. doi: 10.1186/s12974-018-1248-8.

Marino F, Scanzano A, Pulze L, Pinoli M, Rasini E, Luini A, Bombelli R, Legnaro M, de Eguileor M, Cosentino M. β2 -Adrenoceptors inhibit neutrophil extracellular traps in human polymorphonuclear leukocytes. J Leukoc Biol, 2018, 104(3):603-614. doi: 10.1002/JLB.3A1017-398RR.

Cosentino M, Kustrimovic N, Ferrari M, Rasini E, Marino F. cAMP levels in lymphocytes and CD4+ regulatory T-cell functions are affected by dopamine receptor gene polymorphisms. Immunology, 2018, 153(3):337-341. doi: 10.1111/imm.12843.

Pinoli M, Marino F, Cosentino M. Dopaminergic Regulation of Innate Immunity: a Review. J Neuroimmune Pharmacol, 2017, 12(4):602-623. doi: 10.1007/s11481-017-9749-2.

Marino F, Cosentino M. Multiple sclerosis: Repurposing dopaminergic drugs for MS-the evidence mounts. Nat Rev Neurol, 2016, 12(4):191-2. doi: 10.1038/nrneurol.2016.33.
 

  

Miljković Đorđe

Djedovic N, Mansilla MJ, Jevtić B, Navarro-Barriuso J, Saksida T, Martínez-Cáceres EM, Miljković Ð. Ethyl Pyruvate Induces Tolerogenic Dendritic Cells. Front Immunol, 2019, 10:157. doi: 10.3389/fimmu.2019.00157.

Stanisavljević S, Dinić M, Jevtić B, Đedović N, Momčilović M, Đokić J, Golić N, Mostarica Stojković M, Miljković Đ. Gut Microbiota Confers Resistance of Albino Oxford Rats to the Induction of Experimental Autoimmune Encephalomyelitis. Front Immunol, 2018, 9:942. doi: 10.3389/fimmu.2018.00942.

Djedović N, Stanisavljevic S, Jevtić B, Momčilović M, Lavrnja I, Miljković D. Anti-encephalitogenic effects of ethyl pyruvate are reflected in the central nervous system and the gut. Biomed Pharmacother, 2017, 96:78-85. doi: 10.1016/j.biopha.2017.09.110.

Miljković D, Blaževski J, Petković F, Djedović N, Momčilović M, Stanisavljević S, Jevtić B, Mostarica Stojković M, Spasojević I. A comparative analysis of multiple sclerosis-relevant anti-inflammatory properties of ethyl pyruvate and dimethyl fumarate. J Immunol, 2015, 194(6):2493-503. doi: 10.4049/jimmunol.1402302.
 

  

  

Nadjar Agnes

Labrousse VF, Leyrolle Q, Amadieu C, Aubert A, Sere A, Coutureau E, Grégoire S, Bretillon L, Pallet V, Gressens P, Joffre C, Nadjar A, Layé S. Dietary omega-3 deficiency exacerbates inflammation and reveals spatial memory deficits in mice exposed to lipopolysaccharide during gestation. Brain Behav Immun, 2018, 73:427-440. doi: 10.1016/j.bbi.2018.06.004.

Layé S, Nadjar A, Joffre C, Bazinet RP. Anti-Inflammatory Effects of Omega-3 Fatty Acids in the Brain: Physiological Mechanisms and Relevance to Pharmacology. Pharmacol Rev, 2018, 70(1):12-38. doi: 10.1124/pr.117.014092.

Delpech JC, Saucisse N, Parkes SL, Lacabanne C, Aubert A, Casenave F, Coutureau E, Sans N, Layé S, Ferreira G, Nadjar A. Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission. J Neurosci, 2015, 35(7):3022-33. doi: 10.1523/JNEUROSCI.3028-14.2015.

Delpech JC, Madore C, Joffre C, Aubert A, Kang JX, Nadjar A, Layé S. Transgenic increase in n-3/n-6 fatty acid ratio protects against cognitive deficits induced by an immune challenge through decrease of neuroinflammation. Neuropsychopharmacology, 2015, 40(3):525-36. doi: 10.1038/npp.2014.196.

Nadjar A, Blutstein T, Aubert A, Laye S, Haydon PG. Astrocyte-derived adenosine modulates increased sleep pressure during inflammatory response. Glia, 2013, 61(5):724-31. doi: 10.1002/glia.22465.

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Rohleder Nicolas

Thoma MV, Gianferante D, Hanlin L, Fiksdal A, Chen X, Rohleder N. Stronger hypothalamus-pituitary-adrenal axis habituation predicts lesser sensitization of inflammatory response to repeated acute stress exposures in healthy young adults. Brain Behav Immun, 2017, 61:228-235. doi: 10.1016/j.bbi.2016.11.030.

Kuras YI, McInnis CM, Thoma MV, Chen X, Hanlin L, Gianferante D, Rohleder N. Increased alpha-amylase response to an acute psychosocial stress challenge in healthy adults with childhood adversity. Dev Psychobiol, 2017, 59(1):91-98. doi: 10.1002/dev.21470.

McInnis CM, Wang D, Gianferante D, Hanlin L, Chen X, Thoma MV, Rohleder N. Response and habituation of pro- and anti-inflammatory gene expression to repeated acute stress. Brain Behav Immun, 2015, 46:237-48. doi: 10.1016/j.bbi.2015.02.006.

Rohleder N, Marin TJ, Ma R, Miller GE. Biologic cost of caring for a cancer patient: dysregulation of pro- and anti-inflammatory signaling pathways. J Clin Oncol, 2009, 27(18):2909-15. doi: 10.1200/JCO.2008.18.7435.

Rohleder N. Stimulation of systemic low-grade inflammation by psychosocial stress. Psychosom Med, 2014, 76(3):181-9. doi: 10.1097/PSY.0000000000000049.

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Rummel Christoph

Sonenberg N, Aguilar-Valles A, Haji N, De Gregorio D, Camacho EM, Eslamizade M, Popic J, Sharma V, Cao R, Rummel C, Tanti A, Wiebe S, Nunez N, Comai S, Nadon R, Luheshi G, Mechawar N, Turecki G, Lacaille JC, Gobbi G. Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E. Nat. Commun, 2018, 9: 2459. doi: 10.1038/s41467-018-04883-5.

Koenig S, Bredehöft J, Perniss A, Fuchs F, Roth J and Rummel C. Age dependent hypothalamic and pituitary responses to novel environment stress or lipopolysaccharide in rats. Front. Behav. Neurosci., 2018, 12: 55. doi: 10.3389/fnbeh.2018.00055.

Schneiders J, Fuchs F, Damm J, Herden C, Gerstberger R, Soares DM, Roth J, Rummel C. The transcription factor nuclear factor interleukin 6 mediates pro- and anti-inflammatory responses during LPS-induced systemic inflammation in mice. Brain Behav Immun, 2015, 48: 147-164. doi: 10.1016/j.bbi.2015.03.008

Koenig S, Luheshi GN, Wenz T, Gerstberger R, Roth J, Rummel C. Leptin is involved in age-dependent changes in response to systemic inflammation in the rat. Brain Behav Immun, 2014, 36: 128-38. doi: 10.1016/j.bbi.2013.10.019.

Rummel C, Inoue W, Poole S, and Luheshi GN. Leptin regulates neutrophil recruitment into the brain following severe systemic LPS-induced inflammation. Mol Psychiatry, 2010, 15: 523-34. doi: 10.1038/mp.2009.98.

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Schoemaker Regien

Tasbihgou SR, Netkova M, Kalmar AF, Doorduin J, Struys MMRF, Schoemaker RG, Absalom AR. Brain changes due to hypoxia during light anaesthesia can be prevented by deepening anaesthesia; a study in rats. PLoS One, 2018, 13(2):e0193062. doi: 10.1371/journal.pone.0193062.

Gouweleeuw L, Hovens IB, van Leeuwen BL, Schoemaker RG. Neutrophil gelatinase-associated lipocalin and microglial activity are associated with distinct postoperative behavioral changes in rats. Behav Brain Res, 2017, 319:104-109. doi: 10.1016/j.bbr.2016.11.023

Gouweleeuw L, Hovens IB, Liu H, Naudé PJW, Schoemaker RG. Differences in the association between behavior and neutrophil gelatinase-associated lipocalin in male and female rats after coronary artery ligation. Physiol Behav, 2016, 163:7-16. doi: 10.1016/j.physbeh.2016.04.040.

Mommersteeg PMC, Schoemaker RG, Naudé PJW, Eisel ULM, Garrelds IM, Schalkwijk CG, Westerhuis BWJJM, Kop WJ, Denollet J. Depression and markers of inflammation as predictors of all-cause mortality in heart failure. Brain Behav Immun, 2016, 57:144-150. doi: 10.1016/j.bbi.2016.03.012.

Hovens IB, Schoemaker RG, van der Zee EA, Absalom AR, Heineman E, van Leeuwen BL. Postoperative cognitive dysfunction: Involvement of neuroinflammation and neuronal functioning. Brain Behav Immun, 2014, 38:202-10. doi: 10.1016/j.bbi.2014.02.002.

 

  

Straub Rainer H

Straub RH. The brain and immune system prompt energy shortage in chronic inflammation and ageing. Nat Rev Rheumatol, 2017, 13(12):743-751. doi: 10.1038/nrrheum.2017.172

Straub RH, Schradin C. Chronic inflammatory systemic diseases: An evolutionary trade-off between acutely beneficial but chronically harmful programs. Evol Med Public Health, 2016, 2016(1):37-51. doi: 10.1093/emph/eow001.

Straub RH. Rheumatoid arthritis: Stress in RA: a trigger of proinflammatory pathways? Nat Rev Rheumatol. 2014 Sep;10(9):516-8. doi: 10.1038/nrrheum.2014.110.

Klatt S, Stangl H, Kunath J, Lowin T, Pongratz G, Straub RH. Peripheral elimination of the sympathetic nervous system stimulates immunocyte retention in lymph nodes and ameliorates collagen type II arthritis. Brain Behav Immun, 2016, 54:201-210. doi: 10.1016/j.bbi.2016.02.006.

Pongratz G, Straub RH. Role of peripheral nerve fibres in acute and chronic inflammation in arthritis. Nat Rev Rheumatol, 2013, 9(2):117-26. doi: 10.1038/nrrheum.2012.181.

 

  

  

van der Schaaf Marieke

Draper A, Koch RM, van der Meer JW, Aj Apps M, Pickkers P, Husain M, van der Schaaf ME. Effort but not Reward Sensitivity is Altered by Acute Sickness Induced by Experimental Endotoxemia in Humans. Neuropsychopharmacology, 2018, 43(5):1107-1118. doi: 10.1038/npp.2017.231

Roerink ME, van der Schaaf ME, Dinarello CA, Knoop H, van der Meer JW. Interleukin-1 as a mediator of fatigue in disease: a narrative review. J Neuroinflammation, 2017, 14(1):16. doi: 10.1186/s12974-017-0796-7

van der Schaaf ME, Roelofs K, de Lange FP, Geurts DEM, van der Meer JWM, Knoop H, Toni I. Fatigue Is Associated With Altered Monitoring and Preparation of Physical Effort in Patients With Chronic Fatigue Syndrome. Biol Psychiatry Cogn Neurosci Neuroimaging, 2018, 3(4):392-404. doi: 10.1016/j.bpsc.2018.01.015

van der Schaaf ME, De Lange FP, Schmits IC, Geurts DEM, Roelofs K, van der Meer JWM, Toni I, Knoop H. Prefrontal Structure Varies as a Function of Pain Symptoms in Chronic Fatigue Syndrome. Biol Psychiatry, 2017, 81(4):358-365. doi: 10.1016/j.biopsych.2016.07.016

van der Schaaf ME, van Schouwenburg MR, Geurts DE, Schellekens AF, Buitelaar JK, Verkes RJ, Cools R. Establishing the dopamine dependency of human striatal signals during reward and punishment reversal learning. Cereb Cortex, 2014, 24(3):633-42. doi: 10.1093/cercor/bhs344

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